Names & Taxonomy
- Uniprot ID:
- Q13255
- Entry Name:
- GRM1_HUMAN
- Status:
- reviewed
- Protein Names:
- Metabotropic glutamate receptor 1 (mGluR1)
- Gene Names:
- GRM1 GPRC1A MGLUR1
- Gene Names Primary:
- GRM1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1194
- Sequence:
- MVGLLLFFFPAIFLEVSLLPRSPGRKVLLAGASSQRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKPIAGVIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGNESLEENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKIQMNKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNADLTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKICTRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVRSAFTTSDVVRMHVGDGKLPCRSNTFLNIFRRKKAGAGNANSNGKSVSWSEPGGGQVPKGQHMWHRLSVHVKTNETACNQTAVIKPLTKSYQGSGKSLTFSDTSTKTLYNVEEEEDAQPIRFSPPGSPSMVVHRRVPSAATTPPLPSHLTAEETPLFLAEPALPKGLPPPLQQQQQPPPQQKSLMDQLQGVVSNFSTAIPDFHAVLAGPGGPGNGLRSLYPPPPPPQHLQMLPLQLSTFGEELVSPPADDDDDSERFKLLQEYVYEHEREGNTEEDELEEEEEDLQAASKLTPDDSPALTPPSPFRDSVASGSSVPSSPVSESVLCTPPNVSYASVILRDYKQSSSTL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum.
- Enzyme Regulation:
- ENZYME REGULATION: Signaling is inhibited by the antagonist LY341495. The LY341495 binding site partially overlaps with the glutamate binding site. Signaling is also inhibited by synthetic allosteric regulators, such as FITM (4-fluoro-N-(4-(6-(isopropylamino)pyrimidin-4-yl)thiazol-2-yl)-N-methylbenzamide) that bind in a pocket between the transmembrane helices.
- Gene Ontology Go:
- dendrite
G-protein coupled receptor dimeric complex
G-protein coupled receptor homodimeric complex
integral component of plasma membrane
nucleus
plasma membrane
postsynaptic density
G-protein coupled receptor activity
glutamate receptor activity
activation of MAPK activity
activation of MAPKK activity
cellular response to electrical stimulus
dimeric G-protein coupled receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
G-protein coupled receptor signaling pathway
locomotory behavior
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of sensory perception of pain
sensory perception of pain
synaptic transmission - Gene Ontology Biological Process:
- activation of MAPK activity
activation of MAPKK activity
cellular response to electrical stimulus
dimeric G-protein coupled receptor signaling pathway
G-protein coupled glutamate receptor signaling pathway
G-protein coupled receptor signaling pathway
locomotory behavior
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
protein kinase C-activating G-protein coupled receptor signaling pathway
regulation of sensory perception of pain
sensory perception of pain
synaptic transmission - Gene Ontology Molecular Function:
- glutamate receptor activity
G-protein coupled receptor activity - Gene Ontology Cellular Component:
- dendrite
G-protein coupled receptor dimeric complex
G-protein coupled receptor homodimeric complex
integral component of plasma membrane
nucleus
plasma membrane
postsynaptic density - Keywords:
- 3D-structure
Alternative splicing
Cell membrane
Complete proteome
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane
Neurodegeneration
Phosphoprotein
Polymorphism
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix - Interacts With:
- P52294