Names & Taxonomy
- Uniprot ID:
- Q13093
- Entry Name:
- PAFA_HUMAN
- Status:
- reviewed
- Protein Names:
- Platelet-activating factor acetylhydrolase (PAF acetylhydrolase) (EC 3.1.1.47) (1-alkyl-2-acetylglycerophosphocholine esterase) (2-acetyl-1-alkylglycerophosphocholine esterase) (Group-VIIA phospholipase A2) (gVIIA-PLA2) (LDL-associated phospholipase A2) (LDL-PLA(2)) (PAF 2-acylhydrolase)
- Gene Names:
- PLA2G7 PAFAH
- Gene Names Primary:
- PLA2G7
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 441
- Sequence:
- MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space.
Function
- Function:
- Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
- Catalytic Activity:
- 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
- Active Site:
- ACT_SITE 273 273 Nucleophile.
- Gene Ontology Go:
- cytoplasm
extracellular region
low-density lipoprotein particle
1-alkyl-2-acetylglycerophosphocholine esterase activity
calcium-independent phospholipase A2 activity
phospholipid binding
cellular protein metabolic process
lipid catabolic process
lipid oxidation
low-density lipoprotein particle remodeling
plasma lipoprotein particle oxidation
positive regulation of inflammatory response
positive regulation of monocyte chemotaxis - Gene Ontology Biological Process:
- cellular protein metabolic process
lipid catabolic process
lipid oxidation
low-density lipoprotein particle remodeling
plasma lipoprotein particle oxidation
positive regulation of inflammatory response
positive regulation of monocyte chemotaxis - Gene Ontology Molecular Function:
- 1-alkyl-2-acetylglycerophosphocholine esterase activity
calcium-independent phospholipase A2 activity
phospholipid binding - Gene Ontology Cellular Component:
- cytoplasm
extracellular region
low-density lipoprotein particle - Keywords:
- 3D-structure
Asthma
Complete proteome
Direct protein sequencing
Disease mutation
Glycoprotein
Hydrolase
Lipid degradation
Lipid metabolism
Polymorphism
Reference proteome
Secreted
Signal