Names & Taxonomy

Uniprot ID:
Q12906
Entry Name:
ILF3_HUMAN
Status:
reviewed
Protein Names:
Interleukin enhancer-binding factor 3 (Double-stranded RNA-binding protein 76) (DRBP76) (M-phase phosphoprotein 4) (MPP4) (Nuclear factor associated with dsRNA) (NFAR) (Nuclear factor of activated T-cells 90 kDa) (NF-AT-90) (Translational control protein 80) (TCP80)
Gene Names:
ILF3 DRBF MPHOSPH4 NF90
Gene Names Primary:
ILF3
Organism:
Homo sapiens (Human)

Structure

Length:
894
Sequence:
MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localizes in the cytoplasm in response to viral dsRNA. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Function

Function:
May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N-methyltransferase 1 activity. May regulate transcription of the IL2 gene during T-cell activation. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication (By similarity).
Gene Ontology Go:
cytoplasm
intracellular ribonucleoprotein complex
membrane
mitochondrion
nucleolus
nucleoplasm
nucleus
DNA binding
double-stranded RNA binding
poly(A) RNA binding
RNA binding
defense response to virus
negative regulation of transcription, DNA-templated
negative regulation of translation
negative regulation of viral genome replication
positive regulation of transcription, DNA-templated
protein phosphorylation
transcription, DNA-templated
Gene Ontology Biological Process:
defense response to virus
negative regulation of transcription, DNA-templated
negative regulation of translation
negative regulation of viral genome replication
positive regulation of transcription, DNA-templated
protein phosphorylation
transcription, DNA-templated
Gene Ontology Molecular Function:
DNA binding
double-stranded RNA binding
poly(A) RNA binding
RNA binding
Gene Ontology Cellular Component:
cytoplasm
intracellular ribonucleoprotein complex
membrane
mitochondrion
nucleolus
nucleoplasm
nucleus
Keywords:
3D-structure
Acetylation
Alternative splicing
Antiviral defense
Complete proteome
Cytoplasm
DNA-binding
Direct protein sequencing
Methylation
Nucleus
Phosphoprotein
Polymorphism
RNA-binding
Reference proteome
Repeat
Transcription
Transcription regulation
Interacts With:
P03496; Q99873; Q05127

Publication

PubMed ID:
7519613 10400669 10607473 11167023 11438536 11161820 14702039 15057824 15489334 8885239 9442054 10574923 10749851 11777942 12429849 11739746 14570900 15254228 17081983 16964243 17890166 17932509 17289661 18669648 19413330 19029303 19690332 19608861 21123651 20068231 21269460 21406692 24275569