Names & Taxonomy

Uniprot ID:
Q12866
Entry Name:
MERTK_HUMAN
Status:
reviewed
Protein Names:
Tyrosine-protein kinase Mer (EC 2.7.10.1) (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK)
Gene Names:
MERTK MER
Gene Names Primary:
MERTK
Organism:
Homo sapiens (Human)

Structure

Length:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Catalytic Activity:
ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
Active Site:
ACT_SITE 723 723 Proton acceptor.
Gene Ontology Go:
cytoplasm
extracellular space
integral component of plasma membrane
photoreceptor outer segment
plasma membrane
rhabdomere
ATP binding
transmembrane receptor protein tyrosine kinase activity
apoptotic cell clearance
blood coagulation
cell surface receptor signaling pathway
cell-cell signaling
leukocyte migration
natural killer cell differentiation
negative regulation of leukocyte apoptotic process
negative regulation of lymphocyte activation
peptidyl-tyrosine phosphorylation
phagocytosis
platelet activation
positive regulation of phagocytosis
protein kinase B signaling
protein phosphorylation
retina development in camera-type eye
secretion by cell
spermatogenesis
substrate adhesion-dependent cell spreading
vagina development
Gene Ontology Biological Process:
apoptotic cell clearance
blood coagulation
cell-cell signaling
cell surface receptor signaling pathway
leukocyte migration
natural killer cell differentiation
negative regulation of leukocyte apoptotic process
negative regulation of lymphocyte activation
peptidyl-tyrosine phosphorylation
phagocytosis
platelet activation
positive regulation of phagocytosis
protein kinase B signaling
protein phosphorylation
retina development in camera-type eye
secretion by cell
spermatogenesis
substrate adhesion-dependent cell spreading
vagina development
Gene Ontology Molecular Function:
ATP binding
transmembrane receptor protein tyrosine kinase activity
Gene Ontology Cellular Component:
cytoplasm
extracellular space
integral component of plasma membrane
photoreceptor outer segment
plasma membrane
rhabdomere
Keywords:
3D-structure
ATP-binding
Complete proteome
Disease mutation
Disulfide bond
Glycoprotein
Immunoglobulin domain
Kinase
Membrane
Nucleotide-binding
Phosphoprotein
Polymorphism
Proto-oncogene
Receptor
Reference proteome
Repeat
Retinitis pigmentosa
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase

Publication

PubMed ID:
8086340 11062461 15815621 8702477 9160883 12920122 16288044 16335952 16737840 17005688 18421305 19369195 21792939 17344846 21602930