Names & Taxonomy
- Uniprot ID:
- Q12860
- Entry Name:
- CNTN1_HUMAN
- Status:
- reviewed
- Protein Names:
- Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)
- Gene Names:
- CNTN1
- Gene Names Primary:
- CNTN1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1018
- Sequence:
- MKMWLLVSHLVIISITTCLAEFTWYRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.
Function
- Function:
- Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
- Gene Ontology Go:
- anchored component of membrane
extracellular exosome
membrane
membrane raft
myelin sheath
plasma membrane
carbohydrate binding
axon guidance
cell adhesion
cerebellum development
Notch signaling pathway
positive regulation of gene expression
positive regulation of neuron projection development
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of sodium ion transport - Gene Ontology Biological Process:
- axon guidance
cell adhesion
cerebellum development
Notch signaling pathway
positive regulation of gene expression
positive regulation of neuron projection development
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of sodium ion transport - Gene Ontology Molecular Function:
- carbohydrate binding
- Gene Ontology Cellular Component:
- anchored component of membrane
extracellular exosome
membrane
membrane raft
myelin sheath
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
GPI-anchor
Glycoprotein
Immunoglobulin domain
Lipoprotein
Membrane
Notch signaling pathway
Polymorphism
Reference proteome
Repeat
Signal