Names & Taxonomy

Uniprot ID:
Q12860
Entry Name:
CNTN1_HUMAN
Status:
reviewed
Protein Names:
Contactin-1 (Glycoprotein gp135) (Neural cell surface protein F3)
Gene Names:
CNTN1
Gene Names Primary:
CNTN1
Organism:
Homo sapiens (Human)

Structure

Length:
1018
Sequence:
MKMWLLVSHLVIISITTCLAEFTWYRRYGHGVSEEDKGFGPIFEEQPINTIYPEESLEGKVSLNCRARASPFPVYKWRMNNGDVDLTSDRYSMVGGNLVINNPDKQKDAGIYYCLASNNYGMVRSTEATLSFGYLDPFPPEERPEVRVKEGKGMVLLCDPPYHFPDDLSYRWLLNEFPVFITMDKRRFVSQTNGNLYIANVEASDKGNYSCFVSSPSITKSVFSKFIPLIPIPERTTKPYPADIVVQFKDVYALMGQNVTLECFALGNPVPDIRWRKVLEPMPSTAEISTSGAVLKIFNIQLEDEGIYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIRWLKNGYAYHKGELRLYDVTFENAGMYQCIAENTYGAIYANAELKILALAPTFEMNPMKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLEINNITRNDGGIYTCFAENNRGKANSTGTLVITDPTRIILAPINADITVGENATMQCAASFDPALDLTFVWSFNGYVIDFNKENIHYQRNFMLDSNGELLIRNAQLKHAGRYTCTAQTIVDNSSASADLVVRGPPGPPGGLRIEDIRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAKTDPPIIEGNMEAARAVDLIPWMEYEFRVVATNTLGRGEPSIPSNRIKTDGAAPNVAPSDVGGGGGRNRELTITWAPLSREYHYGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDETMSPSTAFQVKVKAFNNKGDGPYSLVAVINSAQDAPSEAPTEVGVKVLSSSEISVHWEHVLEKIVESYQIRYWAAHDKEEAANRVQVTSQEYSARLENLLPDTQYFIEVGACNSAGCGPPSDMIEAFTKKAPPSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKVLYRPDGQHDGKLYSTHKHSIEVPIPRDGEYVVEVRAHSDGGDGVVSQVKISGAPTLSPSLLGLLLPAFGILVYLEF
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.; Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side.

Function

Function:
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
Gene Ontology Go:
anchored component of membrane
extracellular exosome
membrane
membrane raft
myelin sheath
plasma membrane
carbohydrate binding
axon guidance
cell adhesion
cerebellum development
Notch signaling pathway
positive regulation of gene expression
positive regulation of neuron projection development
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of sodium ion transport
Gene Ontology Biological Process:
axon guidance
cell adhesion
cerebellum development
Notch signaling pathway
positive regulation of gene expression
positive regulation of neuron projection development
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of sodium ion transport
Gene Ontology Molecular Function:
carbohydrate binding
Gene Ontology Cellular Component:
anchored component of membrane
extracellular exosome
membrane
membrane raft
myelin sheath
plasma membrane
Keywords:
3D-structure
Alternative splicing
Cell adhesion
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
GPI-anchor
Glycoprotein
Immunoglobulin domain
Lipoprotein
Membrane
Notch signaling pathway
Polymorphism
Reference proteome
Repeat
Signal

Publication

PubMed ID:
8164510 7959734 14702039 15489334 2026173 16335952 19139490 20133774 16959974 19026398