Names & Taxonomy

Uniprot ID:
Q12809
Entry Name:
KCNH2_HUMAN
Status:
reviewed
Protein Names:
Potassium voltage-gated channel subfamily H member 2 (Eag homolog) (Ether-a-go-go-related gene potassium channel 1) (ERG-1) (Eag-related protein 1) (Ether-a-go-go-related protein 1) (H-ERG) (hERG-1) (hERG1) (Voltage-gated potassium channel subunit Kv11.1)
Gene Names:
KCNH2 ERG ERG1 HERG
Gene Names Primary:
KCNH2
Organism:
Homo sapiens (Human)

Structure

Length:
1159
Sequence:
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPPTSWLAPGRAKTFRLKLPALLALTARESSVRSGGAGGAGAPGAVVVDVDLTPAAPSSESLALDEVTAMDNHVAGLGPAEERRALVGPGSPPRSAPGQLPSPRAHSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGVLPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAPELPQEGPTRRLSLPGQLGALTSQPLHRHGSDPGS
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane
Intramembrane:
INTRAMEM 612 632 Pore-forming; Name=Segment H5.

Function

Function:
Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoforms USO have no channel activity by themself, but modulates channel characteristics by forming heterotetramers with other isoforms which are retained intracellularly and undergo ubiquitin-dependent degradation.
Cross Reference Drug Bank:
DB00346 DB01118 DB00276 DB00637 DB01136 DB00477 DB00537 DB00604 DB01211 DB00204 DB00590 DB01142 DB04855 DB00199 DB01218 DB00308 DB00458 DB01110 DB01100 DB00457 DB01182 DB00908 DB06144 DB00489 DB01162 DB00679 DB00661
Gene Ontology Go:
cell surface
perinuclear region of cytoplasm
plasma membrane
voltage-gated potassium channel complex
C3HC4-type RING finger domain binding
delayed rectifier potassium channel activity
identical protein binding
inward rectifier potassium channel activity
phosphorelay sensor kinase activity
protein homodimerization activity
scaffold protein binding
ubiquitin protein ligase binding
voltage-gated potassium channel activity
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
cardiac conduction
cardiac muscle contraction
cellular response to drug
membrane depolarization during action potential
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
negative regulation of potassium ion export
negative regulation of potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
potassium ion export
potassium ion export across plasma membrane
potassium ion homeostasis
potassium ion transmembrane transport
regulation of heart rate by cardiac conduction
regulation of heart rate by hormone
regulation of membrane potential
regulation of membrane repolarization
regulation of potassium ion transmembrane transport
regulation of ventricular cardiac muscle cell membrane repolarization
synaptic transmission
ventricular cardiac muscle cell action potential
Gene Ontology Biological Process:
cardiac conduction
cardiac muscle contraction
cellular response to drug
membrane depolarization during action potential
membrane repolarization during action potential
membrane repolarization during cardiac muscle cell action potential
negative regulation of potassium ion export
negative regulation of potassium ion transmembrane transport
positive regulation of potassium ion transmembrane transport
potassium ion export
potassium ion export across plasma membrane
potassium ion homeostasis
potassium ion transmembrane transport
regulation of heart rate by cardiac conduction
regulation of heart rate by hormone
regulation of membrane potential
regulation of membrane repolarization
regulation of potassium ion transmembrane transport
regulation of ventricular cardiac muscle cell membrane repolarization
synaptic transmission
ventricular cardiac muscle cell action potential
Gene Ontology Molecular Function:
C3HC4-type RING finger domain binding
delayed rectifier potassium channel activity
identical protein binding
inward rectifier potassium channel activity
phosphorelay sensor kinase activity
protein homodimerization activity
scaffold protein binding
ubiquitin protein ligase binding
voltage-gated potassium channel activity
voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Gene Ontology Cellular Component:
cell surface
perinuclear region of cytoplasm
plasma membrane
voltage-gated potassium channel complex
Keywords:
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Deafness
Disease mutation
Glycoprotein
Ion channel
Ion transport
Long QT syndrome
Membrane
Phosphoprotein
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Short QT syndrome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel
Interacts With:
Itself; Q03135

Publication

PubMed ID:
8159766 9600240 11374908 12431979 18559421 19412172 12853948 9351462 9351446 10790218 15489334 9765245 12063277 10837251 9230439 10219239 16361248 19690332 9845367 7889573 8914737 8635257 8877771 9024139 9693036 9544837 9452080 10086971 10220144 10187793 10517660 10735633 10973849 10862094 10753933 11170080 12062363 11997281 12442276 12354768 12621127 14676148 15051636 15840476 16414944 15828882 16922724 19716085 22314138