Names & Taxonomy
- Uniprot ID:
- Q12797
- Entry Name:
- ASPH_HUMAN
- Status:
- reviewed
- Protein Names:
- Aspartyl/asparaginyl beta-hydroxylase (EC 1.14.11.16) (Aspartate beta-hydroxylase) (ASP beta-hydroxylase) (Peptide-aspartate beta-dioxygenase)
- Gene Names:
- ASPH BAH
- Gene Names Primary:
- ASPH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 758
- Sequence:
- MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLSGTSFFTWFMVIALLGVWTSVAVVWFDLVDYEEVLGKLGIYDADGDGDFDVDDAKVLLGLKERSTSEPAVPPEEAEPHTEPEEQVPVEAEPQNIEDEAKEQIQSLLHEMVHAEHVEGEDLQQEDGPTGEPQQEDDEFLMATDVDDRFETLEPEVSHEETEHSYHVEETVSQDCNQDMEEMMSEQENPDSSEPVVEDERLHHDTDDVTYQVYEEQAVYEPLENEGIEITEVTAPPEDNPVEDSQVIVEEVSIFPVEEQQEVPPETNRKTDDPEQKAKVKKKKPKLLNKFDKTIKAELDAAEKLRKRGKIEEAVNAFKELVRKYPQSPRARYGKAQCEDDLAEKRRSNEVLRGAIETYQEVASLPDVPADLLKLSLKRRSDRQQFLGHMRGSLLTLQRLVQLFPNDTSLKNDLGVGYLLIGDNDNAKKVYEEVLSVTPNDGFAKVHYGFILKAQNKIAESIPYLKEGIESGDPGTDDGRFYFHLGDAMQRVGNKEAYKWYELGHKRGHFASVWQRSLYNVNGLKAQPWWTPKETGYTELVKSLERNWKLIRDEGLAVMDKAKGLFLPEDENLREKGDWSQFTLWQQGRRNENACKGAPKTCTLLEKFPETTGCRRGQIKYSIMHPGTHVWPHTGPTNCRLRMHLGLVIPKEGCKIRCANETKTWEEGKVLIFDDSFEHEVWQDASSFRLIFIVDVWHPELTPQQRRSLPAI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Function
- Function:
- Isoform 1: specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.
- Catalytic Activity:
- Peptide L-aspartate + 2-oxoglutarate + O(2) = peptide 3-hydroxy-L-aspartate + succinate + CO(2).
- Cofactor:
- COFACTOR: Name=Fe cation; Xref=ChEBI:CHEBI:24875;
- Cross Reference Drug Bank:
- DB00128 DB00139
- Gene Ontology Go:
- calcium channel complex
cortical endoplasmic reticulum
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
integral component of membrane
junctional sarcoplasmic reticulum membrane
plasma membrane
sarcoplasmic reticulum lumen
sarcoplasmic reticulum membrane
calcium ion binding
electron carrier activity
ion channel binding
peptide-aspartate beta-dioxygenase activity
structural constituent of muscle
structural molecule activity
activation of cysteine-type endopeptidase activity
activation of store-operated calcium channel activity
calcium ion transmembrane transport
cardiac conduction
cellular response to calcium ion
detection of calcium ion
face morphogenesis
ion transmembrane transport
limb morphogenesis
muscle contraction
negative regulation of cell proliferation
palate development
pattern specification process
peptidyl-aspartic acid hydroxylation
positive regulation of calcium ion transport into cytosol
positive regulation of intracellular protein transport
positive regulation of proteolysis
positive regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of transcription, DNA-templated
regulation of cardiac conduction
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cell communication by electrical coupling
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
regulation of protein depolymerization
regulation of protein stability
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of ryanodine-sensitive calcium-release channel activity
response to ATP
transmembrane transport - Gene Ontology Biological Process:
- activation of cysteine-type endopeptidase activity
activation of store-operated calcium channel activity
calcium ion transmembrane transport
cardiac conduction
cellular response to calcium ion
detection of calcium ion
face morphogenesis
ion transmembrane transport
limb morphogenesis
muscle contraction
negative regulation of cell proliferation
palate development
pattern specification process
peptidyl-aspartic acid hydroxylation
positive regulation of calcium ion transport into cytosol
positive regulation of intracellular protein transport
positive regulation of proteolysis
positive regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of transcription, DNA-templated
regulation of cardiac conduction
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cell communication by electrical coupling
regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
regulation of protein depolymerization
regulation of protein stability
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of ryanodine-sensitive calcium-release channel activity
response to ATP
transmembrane transport - Gene Ontology Molecular Function:
- calcium ion binding
electron carrier activity
ion channel binding
peptide-aspartate beta-dioxygenase activity
structural constituent of muscle
structural molecule activity - Gene Ontology Cellular Component:
- calcium channel complex
cortical endoplasmic reticulum
endoplasmic reticulum
endoplasmic reticulum membrane
integral component of endoplasmic reticulum membrane
integral component of membrane
junctional sarcoplasmic reticulum membrane
plasma membrane
sarcoplasmic reticulum lumen
sarcoplasmic reticulum membrane - Keywords:
- 3D-structure
Alternative splicing
Calcium
Complete proteome
Dioxygenase
Disease mutation
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Iron
Membrane
Metal-binding
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Sarcoplasmic reticulum
Signal-anchor
TPR repeat
Transmembrane
Transmembrane helix - Interacts With:
- O43681