Names & Taxonomy
- Uniprot ID:
- Q12791
- Entry Name:
- KCMA1_HUMAN
- Status:
- reviewed
- Protein Names:
- Calcium-activated potassium channel subunit alpha-1 (BK channel) (BKCA alpha) (Calcium-activated potassium channel, subfamily M subunit alpha-1) (K(VCA)alpha) (KCa1.1) (Maxi K channel) (MaxiK) (Slo-alpha) (Slo1) (Slowpoke homolog) (Slo homolog) (hSlo)
- Gene Names:
- KCNMA1 KCNMA SLO
- Gene Names Primary:
- KCNMA1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1236
- Sequence:
- MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRPKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKYVQEERL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
- Intramembrane:
- INTRAMEM 336 358 Pore-forming; Name=P region.
Function
- Function:
- Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX).
- Enzyme Regulation:
- ENZYME REGULATION: Ethanol and carbon monoxide-bound heme increase channel activation. Heme inhibits channel activation.
- Cross Reference Drug Bank:
- DB00436 DB00356 DB01003 DB01119 DB01159 DB00999 DB00774 DB01110 DB00721
- Gene Ontology Go:
- apical plasma membrane
caveola
extracellular exosome
integral component of membrane
plasma membrane
voltage-gated potassium channel complex
actin binding
calcium-activated potassium channel activity
large conductance calcium-activated potassium channel activity
metal ion binding
voltage-gated potassium channel activity
blood coagulation
cellular potassium ion homeostasis
micturition
negative regulation of cell volume
positive regulation of apoptotic process
potassium ion transmembrane transport
potassium ion transport
regulation of membrane potential
response to calcium ion
response to carbon monoxide
response to hypoxia
response to osmotic stress
smooth muscle contraction involved in micturition
synaptic transmission - Gene Ontology Biological Process:
- blood coagulation
cellular potassium ion homeostasis
micturition
negative regulation of cell volume
positive regulation of apoptotic process
potassium ion transmembrane transport
potassium ion transport
regulation of membrane potential
response to calcium ion
response to carbon monoxide
response to hypoxia
response to osmotic stress
smooth muscle contraction involved in micturition
synaptic transmission - Gene Ontology Molecular Function:
- actin binding
calcium-activated potassium channel activity
large conductance calcium-activated potassium channel activity
metal ion binding
voltage-gated potassium channel activity - Gene Ontology Cellular Component:
- apical plasma membrane
caveola
extracellular exosome
integral component of membrane
plasma membrane
voltage-gated potassium channel complex - Keywords:
- 3D-structure
Alternative splicing
Calcium
Cell membrane
Complete proteome
Disease mutation
Epilepsy
Ion channel
Ion transport
Lipoprotein
Magnesium
Membrane
Metal-binding
Palmitate
Phosphoprotein
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel