Names & Taxonomy
- Uniprot ID:
- Q10570
- Entry Name:
- CPSF1_HUMAN
- Status:
- reviewed
- Protein Names:
- Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit)
- Gene Names:
- CPSF1 CPSF160
- Gene Names Primary:
- CPSF1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1443
- Sequence:
- MYAVYKQAHPPTGLEFSMYCNFFNNSERNLVVAGTSQLYVYRLNRDAEALTKNDRSTEGKAHREKLELAASFSFFGNVMSMASVQLAGAKRDALLLSFKDAKLSVVEYDPGTHDLKTLSLHYFEEPELRDGFVQNVHTPRVRVDPDGRCAAMLVYGTRLVVLPFRRESLAEEHEGLVGEGQRSSFLPSYIIDVRALDEKLLNIIDLQFLHGYYEPTLLILFEPNQTWPGRVAVRQDTCSIVAISLNITQKVHPVIWSLTSLPFDCTQALAVPKPIGGVVVFAVNSLLYLNQSVPPYGVALNSLTTGTTAFPLRTQEGVRITLDCAQATFISYDKMVISLKGGEIYVLTLITDGMRSVRAFHFDKAAASVLTTSMVTMEPGYLFLGSRLGNSLLLKYTEKLQEPPASAVREAADKEEPPSKKKRVDATAGWSAAGKSVPQDEVDEIEVYGSEAQSGTQLATYSFEVCDSILNIGPCANAAVGEPAFLSEEFQNSPEPDLEIVVCSGHGKNGALSVLQKSIRPQVVTTFELPGCYDMWTVIAPVRKEEEDNPKGEGTEQEPSTTPEADDDGRRHGFLILSREDSTMILQTGQEIMELDTSGFATQGPTVFAGNIGDNRYIVQVSPLGIRLLEGVNQLHFIPVDLGAPIVQCAVADPYVVIMSAEGHVTMFLLKSDSYGGRHHRLALHKPPLHHQSKVITLCLYRDLSGMFTTESRLGGARDELGGRSGPEAEGLGSETSPTVDDEEEMLYGDSGSLFSPSKEEARRSSQPPADRDPAPFRAEPTHWCLLVRENGTMEIYQLPDWRLVFLVKNFPVGQRVLVDSSFGQPTTQGEARREEATRQGELPLVKEVLLVALGSRQSRPYLLVHVDQELLIYEAFPHDSQLGQGNLKVRFKKVPHNINFREKKPKPSKKKAEGGGAEEGAGARGRVARFRYFEDIYGYSGVFICGPSPHWLLVTGRGALRLHPMAIDGPVDSFAPFHNVNCPRGFLYFNRQGELRISVLPAYLSYDAPWPVRKIPLRCTAHYVAYHVESKVYAVATSTNTPCARIPRMTGEEKEFETIERDERYIHPQQEAFSIQLISPVSWEAIPNARIELQEWEHVTCMKTVSLRSEETVSGLKGYVAAGTCLMQGEEVTCRGRILIMDVIEVVPEPGQPLTKNKFKVLYEKEQKGPVTALCHCNGHLVSAIGQKIFLWSLRASELTGMAFIDTQLYIHQMISVKNFILAADVMKSISLLRYQEESKTLSLVSRDAKPLEVYSVDFMVDNAQLGFLVSDRDRNLMVYMYLPEAKESFGGMRLLRRADFHVGAHVNTFWRTPCRGATEGLSKKSVVWENKHITWFATLDGGIGLLLPMQEKTYRRLLMLQNALTTMLPHHAGLNPRAFRMLHVDRRTLQNAVRNVLDGELLNRYLYLSTMERSELAKKIGTTPDIILDDLLETDRVTAHF
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nucleoplasm.
Function
- Function:
- Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction.
- Gene Ontology Go:
- mRNA cleavage and polyadenylation specificity factor complex
nucleoplasm
enzyme binding
mRNA 3'-UTR AU-rich region binding
gene expression
mRNA 3'-end processing
mRNA cleavage
mRNA export from nucleus
mRNA polyadenylation
mRNA splicing, via spliceosome
pre-mRNA cleavage required for polyadenylation
RNA splicing
termination of RNA polymerase II transcription
transcription from RNA polymerase II promoter
tRNA processing - Gene Ontology Biological Process:
- gene expression
mRNA 3'-end processing
mRNA cleavage
mRNA export from nucleus
mRNA polyadenylation
mRNA splicing, via spliceosome
pre-mRNA cleavage required for polyadenylation
RNA splicing
termination of RNA polymerase II transcription
transcription from RNA polymerase II promoter
tRNA processing - Gene Ontology Molecular Function:
- enzyme binding
mRNA 3'-UTR AU-rich region binding - Gene Ontology Cellular Component:
- mRNA cleavage and polyadenylation specificity factor complex
nucleoplasm - Keywords:
- Complete proteome
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
mRNA processing - Interacts With:
- P06748; Q04864