Names & Taxonomy
- Uniprot ID:
- Q0PHS1
- Entry Name:
- Q0PHS1_HUMAN
- Status:
- unreviewed
- Protein Names:
- Glucose-6-phosphate 1-dehydrogenase (EC 1.1.1.49) (Fragment)
- Gene Names:
- G6PD
- Gene Names Primary:
- G6PD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 297
- Sequence:
- WLFRDGLLPENTFIMGYARSRLTVADIRKQSEPFFKATPEEKLKLEDFFARNSYVAGQYDDAASYQRLNSHMNALHLGSQANRLFYLALPPTVYEAVTKNIHESCMSQIGWNRIIVEKPFGRDLQSSDRLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTNSDDVRDEKVKMLKCISEVQANNVVLGQYVGNPDGEGEATKGYLDDPTVPRGSTTATFAAVVLYVENERWD
Function
- Function:
- Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis.
- Pathway:
- Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.
- Catalytic Activity:
- D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH.
- Gene Ontology Go:
- glucose-6-phosphate dehydrogenase activity
NADP binding
glucose metabolic process
pentose-phosphate shunt - Gene Ontology Biological Process:
- glucose metabolic process
pentose-phosphate shunt - Gene Ontology Molecular Function:
- glucose-6-phosphate dehydrogenase activity
NADP binding - Keywords:
- Carbohydrate metabolism
Glucose metabolism
NADP
Oxidoreductase