Names & Taxonomy
- Uniprot ID:
- Q08493
- Entry Name:
- PDE4C_HUMAN
- Status:
- reviewed
- Protein Names:
- cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC 3.1.4.53) (DPDE1) (PDE21)
- Gene Names:
- PDE4C DPDE1
- Gene Names Primary:
- PDE4C
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 712
- Sequence:
- MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERDLSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESFLYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGAAKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRILNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFELTLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell projection, cilium
Function
- Function:
- Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
- Pathway:
- Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
- Catalytic Activity:
- Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by rolipram.
- Active Site:
- ACT_SITE 388 388 Proton donor.
- Cross Reference Drug Bank:
- DB00201 DB00651 DB05266 DB01088 DB00920 DB01656
- Gene Ontology Go:
- cytosol
extracellular space
primary cilium
3',5'-cyclic-AMP phosphodiesterase activity
drug binding
metal ion binding
cAMP catabolic process
negative regulation of insulin secretion
signal transduction - Gene Ontology Biological Process:
- cAMP catabolic process
negative regulation of insulin secretion
signal transduction - Gene Ontology Molecular Function:
- 3',5'-cyclic-AMP phosphodiesterase activity
drug binding
metal ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular space
primary cilium - Keywords:
- 3D-structure
Alternative splicing
Cell projection
Cilium
Complete proteome
Hydrolase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
cAMP - Interacts With:
- P30626