Names & Taxonomy
- Uniprot ID:
- Q08345
- Entry Name:
- DDR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
- Gene Names:
- DDR1 CAK EDDR1 NEP NTRK4 PTK3A RTK6 TRKE
- Gene Names Primary:
- DDR1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 913
- Sequence:
- MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAARHSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRLRYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRVELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDDFRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGGVECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFSEISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILIGCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPREPPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNTQAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGPPRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLHRFLAEDALNTV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Cell membrane; Single-pass type I membrane protein.; Isoform 3: Secreted
Function
- Function:
- Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
- Catalytic Activity:
- ATP + a -L-tyrosine = ADP + a -L-tyrosine phosphate.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by the multi-targeted cancer drugs imatinib and ponatinib.
- Active Site:
- ACT_SITE 766 766 Proton acceptor.
- Cross Reference Drug Bank:
- DB00619
- Gene Ontology Go:
- basolateral plasma membrane
extracellular exosome
extracellular space
integral component of plasma membrane
plasma membrane
receptor complex
ATP binding
collagen binding
metal ion binding
protein tyrosine kinase collagen receptor activity
transmembrane receptor protein tyrosine kinase activity
branching involved in mammary gland duct morphogenesis
cell adhesion
collagen-activated tyrosine kinase receptor signaling pathway
ear development
embryo implantation
extracellular matrix organization
lactation
mammary gland alveolus development
negative regulation of cell proliferation
organ regeneration
peptidyl-tyrosine autophosphorylation
protein autophosphorylation
regulation of cell growth
regulation of cell-matrix adhesion
regulation of extracellular matrix disassembly
skin development
smooth muscle cell migration
smooth muscle cell-matrix adhesion
wound healing, spreading of cells - Gene Ontology Biological Process:
- branching involved in mammary gland duct morphogenesis
cell adhesion
collagen-activated tyrosine kinase receptor signaling pathway
ear development
embryo implantation
extracellular matrix organization
lactation
mammary gland alveolus development
negative regulation of cell proliferation
organ regeneration
peptidyl-tyrosine autophosphorylation
protein autophosphorylation
regulation of cell growth
regulation of cell-matrix adhesion
regulation of extracellular matrix disassembly
skin development
smooth muscle cell-matrix adhesion
smooth muscle cell migration
wound healing, spreading of cells - Gene Ontology Molecular Function:
- ATP binding
collagen binding
metal ion binding
protein tyrosine kinase collagen receptor activity
transmembrane receptor protein tyrosine kinase activity - Gene Ontology Cellular Component:
- basolateral plasma membrane
extracellular exosome
extracellular space
integral component of plasma membrane
plasma membrane
receptor complex - Keywords:
- 3D-structure
ATP-binding
Alternative splicing
Calcium
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Kinase
Lactation
Membrane
Metal-binding
Nucleotide-binding
Phosphoprotein
Polymorphism
Pregnancy
Receptor
Reference proteome
Secreted
Signal
Transferase
Transmembrane
Transmembrane helix
Tyrosine-protein kinase - Interacts With:
- O43639; Q06124