Names & Taxonomy
- Uniprot ID:
- Q08188
- Entry Name:
- TGM3_HUMAN
- Status:
- reviewed
- Protein Names:
- Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain]
- Gene Names:
- TGM3
- Gene Names Primary:
- TGM3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 693
- Sequence:
- MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVSTGPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQGGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQFEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGTYTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSAHDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQEPSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLEVLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFDILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE
- Proteomes:
- UP000005640
Function
- Function:
- Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
- Catalytic Activity:
- Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
- Cofactor:
- COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
- Active Site:
- ACT_SITE 273 273
- Cross Reference Drug Bank:
- DB00130
- Gene Ontology Go:
- cytoplasm
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
calcium ion binding
catalytic activity
protein-glutamine gamma-glutamyltransferase activity
transferase activity, transferring acyl groups
cell envelope organization
cellular protein modification process
hair follicle morphogenesis
keratinization
keratinocyte differentiation
peptide cross-linking
protein tetramerization - Gene Ontology Biological Process:
- cell envelope organization
cellular protein modification process
hair follicle morphogenesis
keratinization
keratinocyte differentiation
peptide cross-linking
protein tetramerization - Gene Ontology Molecular Function:
- calcium ion binding
catalytic activity
protein-glutamine gamma-glutamyltransferase activity
transferase activity, transferring acyl groups - Gene Ontology Cellular Component:
- cytoplasm
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane - Keywords:
- 3D-structure
Acetylation
Acyltransferase
Calcium
Complete proteome
Direct protein sequencing
Keratinization
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Zymogen