Names & Taxonomy

Uniprot ID:
Q08188
Entry Name:
TGM3_HUMAN
Status:
reviewed
Protein Names:
Protein-glutamine gamma-glutamyltransferase E (EC 2.3.2.13) (Transglutaminase E) (TG(E)) (TGE) (TGase E) (Transglutaminase-3) (TGase-3) [Cleaved into: Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain; Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain]
Gene Names:
TGM3
Gene Names Primary:
TGM3
Organism:
Homo sapiens (Human)

Structure

Length:
693
Sequence:
MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVSTGPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQGGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQFEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGTYTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSAHDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQEPSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLEVLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFDILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE
Proteomes:
UP000005640

Function

Function:
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
Catalytic Activity:
Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3).
Cofactor:
COFACTOR: Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
Active Site:
ACT_SITE 273 273
Cross Reference Drug Bank:
DB00130
Gene Ontology Go:
cytoplasm
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
calcium ion binding
catalytic activity
protein-glutamine gamma-glutamyltransferase activity
transferase activity, transferring acyl groups
cell envelope organization
cellular protein modification process
hair follicle morphogenesis
keratinization
keratinocyte differentiation
peptide cross-linking
protein tetramerization
Gene Ontology Biological Process:
cell envelope organization
cellular protein modification process
hair follicle morphogenesis
keratinization
keratinocyte differentiation
peptide cross-linking
protein tetramerization
Gene Ontology Molecular Function:
calcium ion binding
catalytic activity
protein-glutamine gamma-glutamyltransferase activity
transferase activity, transferring acyl groups
Gene Ontology Cellular Component:
cytoplasm
extracellular exosome
extrinsic component of cytoplasmic side of plasma membrane
Keywords:
3D-structure
Acetylation
Acyltransferase
Calcium
Complete proteome
Direct protein sequencing
Keratinization
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Zymogen

Publication

PubMed ID:
8099584 14702039 11780052 15489334 16565075 19690332 21269460 11980702 12679341