Names & Taxonomy

Uniprot ID:
Q07973
Entry Name:
CP24A_HUMAN
Status:
reviewed
Protein Names:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24)
Gene Names:
CYP24A1 CYP24
Gene Names Primary:
CYP24A1
Organism:
Homo sapiens (Human)

Structure

Length:
514
Sequence:
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Mitochondrion.

Function

Function:
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
Catalytic Activity:
Calcitriol + 2 reduced adrenodoxin + 2 H(+) + O(2) = calcitetrol + 2 oxidized adrenodoxin + H(2)O.
Cofactor:
COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
Cross Reference Drug Bank:
DB00146 DB02300 DB00136 DB01285 DB00153 DB00910
Gene Ontology Go:
mitochondrial inner membrane
mitochondrion
nucleoplasm
nucleus
plasma membrane
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
25-hydroxycholecalciferol-24-hydroxylase activity
heme binding
iron ion binding
oxidoreductase activity
fat-soluble vitamin metabolic process
osteoblast differentiation
oxidation-reduction process
response to vitamin D
small molecule metabolic process
vitamin D catabolic process
vitamin D metabolic process
vitamin D receptor signaling pathway
vitamin metabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
fat-soluble vitamin metabolic process
osteoblast differentiation
oxidation-reduction process
response to vitamin D
small molecule metabolic process
vitamin D catabolic process
vitamin D metabolic process
vitamin D receptor signaling pathway
vitamin metabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
25-hydroxycholecalciferol-24-hydroxylase activity
heme binding
iron ion binding
oxidoreductase activity
Gene Ontology Cellular Component:
mitochondrial inner membrane
mitochondrion
nucleoplasm
nucleus
plasma membrane
Keywords:
Alternative splicing
Complete proteome
Disease mutation
Heme
Iron
Metal-binding
Mitochondrion
Monooxygenase
NADP
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide

Publication

PubMed ID:
8506296 15788398 11780052 15489334 7632726 8266831 15574355 21675912