Names & Taxonomy
- Uniprot ID:
- Q07973
- Entry Name:
- CP24A_HUMAN
- Status:
- reviewed
- Protein Names:
- 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24)
- Gene Names:
- CYP24A1 CYP24
- Gene Names Primary:
- CYP24A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 514
- Sequence:
- MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
- Catalytic Activity:
- Calcitriol + 2 reduced adrenodoxin + 2 H(+) + O(2) = calcitetrol + 2 oxidized adrenodoxin + H(2)O.
- Cofactor:
- COFACTOR: Name=heme; Xref=ChEBI:CHEBI:30413;
- Cross Reference Drug Bank:
- DB00146 DB02300 DB00136 DB01285 DB00153 DB00910
- Gene Ontology Go:
- mitochondrial inner membrane
mitochondrion
nucleoplasm
nucleus
plasma membrane
1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
25-hydroxycholecalciferol-24-hydroxylase activity
heme binding
iron ion binding
oxidoreductase activity
fat-soluble vitamin metabolic process
osteoblast differentiation
oxidation-reduction process
response to vitamin D
small molecule metabolic process
vitamin D catabolic process
vitamin D metabolic process
vitamin D receptor signaling pathway
vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- fat-soluble vitamin metabolic process
osteoblast differentiation
oxidation-reduction process
response to vitamin D
small molecule metabolic process
vitamin D catabolic process
vitamin D metabolic process
vitamin D receptor signaling pathway
vitamin metabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
25-hydroxycholecalciferol-24-hydroxylase activity
heme binding
iron ion binding
oxidoreductase activity - Gene Ontology Cellular Component:
- mitochondrial inner membrane
mitochondrion
nucleoplasm
nucleus
plasma membrane - Keywords:
- Alternative splicing
Complete proteome
Disease mutation
Heme
Iron
Metal-binding
Mitochondrion
Monooxygenase
NADP
Oxidoreductase
Polymorphism
Reference proteome
Transit peptide