Names & Taxonomy
- Uniprot ID:
- Q07837
- Entry Name:
- SLC31_HUMAN
- Status:
- reviewed
- Protein Names:
- Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)
- Gene Names:
- SLC3A1 RBAT
- Gene Names Primary:
- SLC3A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 685
- Sequence:
- MAEDKSKRDSIEMSMKGCQTNNGFVHNEDILEQTPDPGSSTDNLKHSTRGILGSQEPDFKGVQPYAGMPKEVLFQFSGQARYRIPREILFWLTVASVLVLIAATIAIIALSPKCLDWWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWHDCTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVRSFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVSGNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLNILYTSC
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
Function
- Function:
- Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule.
- Cross Reference Drug Bank:
- DB00138
- Gene Ontology Go:
- brush border membrane
extracellular exosome
integral component of plasma membrane
membrane
mitochondrial inner membrane
plasma membrane
vacuolar membrane
amino acid transmembrane transporter activity
basic amino acid transmembrane transporter activity
catalytic activity
cation binding
L-cystine transmembrane transporter activity
amino acid transmembrane transport
amino acid transport
basic amino acid transmembrane transport
basic amino acid transport
carbohydrate metabolic process
cellular amino acid metabolic process
ion transport
L-cystine transport
transmembrane transport - Gene Ontology Biological Process:
- amino acid transmembrane transport
amino acid transport
basic amino acid transmembrane transport
basic amino acid transport
carbohydrate metabolic process
cellular amino acid metabolic process
ion transport
L-cystine transport
transmembrane transport - Gene Ontology Molecular Function:
- amino acid transmembrane transporter activity
basic amino acid transmembrane transporter activity
catalytic activity
cation binding
L-cystine transmembrane transporter activity - Gene Ontology Cellular Component:
- brush border membrane
extracellular exosome
integral component of plasma membrane
membrane
mitochondrial inner membrane
plasma membrane
vacuolar membrane - Keywords:
- Alternative splicing
Amino-acid transport
Complete proteome
Cystinuria
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Transport