Names & Taxonomy

Uniprot ID:
Q07837
Entry Name:
SLC31_HUMAN
Status:
reviewed
Protein Names:
Neutral and basic amino acid transport protein rBAT (NBAT) (D2h) (Solute carrier family 3 member 1) (b(0,+)-type amino acid transport protein)
Gene Names:
SLC3A1 RBAT
Gene Names Primary:
SLC3A1
Organism:
Homo sapiens (Human)

Structure

Length:
685
Sequence:
MAEDKSKRDSIEMSMKGCQTNNGFVHNEDILEQTPDPGSSTDNLKHSTRGILGSQEPDFKGVQPYAGMPKEVLFQFSGQARYRIPREILFWLTVASVLVLIAATIAIIALSPKCLDWWQEGPMYQIYPRSFKDSNKDGNGDLKGIQDKLDYITALNIKTVWITSFYKSSLKDFRYGVEDFREVDPIFGTMEDFENLVAAIHDKGLKLIIDFIPNHTSDKHIWFQLSRTRTGKYTDYYIWHDCTHENGKTIPPNNWLSVYGNSSWHFDEVRNQCYFHQFMKEQPDLNFRNPDVQEEIKEILRFWLTKGVDGFSLDAVKFLLEAKHLRDEIQVNKTQIPDTVTQYSELYHDFTTTQVGMHDIVRSFRQTMDQYSTEPGRYRFMGTEAYAESIDRTVMYYGLPFIQEADFPFNNYLSMLDTVSGNSVYEVITSWMENMPEGKWPNWMIGGPDSSRLTSRLGNQYVNVMNMLLFTLPGTPITYYGEEIGMGNIVAANLNESYDINTLRSKSPMQWDNSSNAGFSEASNTWLPTNSDYHTVNVDVQKTQPRSALKLYQDLSLLHANELLLNRGWFCHLRNDSHYVVYTRELDGIDRIFIVVLNFGESTLLNLHNMISGLPAKMRIRLSTNSADKGSKVDTSGIFLDKGEGLIFEHNTKNLLHRQTAFRDRCFVSNRACYSSVLNILYTSC
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
Involved in the high-affinity, sodium-independent transport of cystine and neutral and dibasic amino acids (system B(0,+)-like activity). May function as an activator of SLC7A9 and be involved in the high-affinity reabsorption of cystine in the kidney tubule.
Cross Reference Drug Bank:
DB00138
Gene Ontology Go:
brush border membrane
extracellular exosome
integral component of plasma membrane
membrane
mitochondrial inner membrane
plasma membrane
vacuolar membrane
amino acid transmembrane transporter activity
basic amino acid transmembrane transporter activity
catalytic activity
cation binding
L-cystine transmembrane transporter activity
amino acid transmembrane transport
amino acid transport
basic amino acid transmembrane transport
basic amino acid transport
carbohydrate metabolic process
cellular amino acid metabolic process
ion transport
L-cystine transport
transmembrane transport
Gene Ontology Biological Process:
amino acid transmembrane transport
amino acid transport
basic amino acid transmembrane transport
basic amino acid transport
carbohydrate metabolic process
cellular amino acid metabolic process
ion transport
L-cystine transport
transmembrane transport
Gene Ontology Molecular Function:
amino acid transmembrane transporter activity
basic amino acid transmembrane transporter activity
catalytic activity
cation binding
L-cystine transmembrane transporter activity
Gene Ontology Cellular Component:
brush border membrane
extracellular exosome
integral component of plasma membrane
membrane
mitochondrial inner membrane
plasma membrane
vacuolar membrane
Keywords:
Alternative splicing
Amino-acid transport
Complete proteome
Cystinuria
Disease mutation
Disulfide bond
Glycoprotein
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix
Transport

Publication

PubMed ID:
8486766 7686906 8663184 9186880 11318953 15913950 14702039 15815621 15489334 10588648 7568194 12167606 16385448 8054986 7539209 7573036 7575432 10738006 11748844 12234283 16138908 15635077 16609684 19782624