Names & Taxonomy
- Uniprot ID:
- Q07343
- Entry Name:
- PDE4B_HUMAN
- Status:
- reviewed
- Protein Names:
- cAMP-specific 3',5'-cyclic phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32)
- Gene Names:
- PDE4B DPDE4
- Gene Names Primary:
- PDE4B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 736
- Sequence:
- MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVLHATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLGETDIDIATEDKSPVDT
- Proteomes:
- UP000005640
Function
- Function:
- Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.
- Pathway:
- Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
- Catalytic Activity:
- Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.
- Cofactor:
- COFACTOR: Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by rolipram.
- Active Site:
- ACT_SITE 406 406 Proton donor.
- Cross Reference Drug Bank:
- DB00131 DB01427 DB05676 DB00201 DB00651 DB00824 DB05266 DB01088 DB00920 DB01113 DB00806 DB01656 DB01412 DB00277
- Gene Ontology Go:
- cell periphery
centrosome
cytosol
dendritic spine
gamma-tubulin complex
membrane
postsynaptic density
synaptic vesicle
Z disc
3',5'-cyclic-AMP phosphodiesterase activity
cAMP binding
ion channel binding
metal ion binding
cAMP catabolic process
cellular response to drug
cellular response to epinephrine stimulus
cellular response to lipopolysaccharide
leukocyte migration
negative regulation of relaxation of cardiac muscle
neutrophil chemotaxis
neutrophil homeostasis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
regulation of cardiac muscle cell contraction
regulation of high voltage-gated calcium channel activity
T cell receptor signaling pathway - Gene Ontology Biological Process:
- cAMP catabolic process
cellular response to drug
cellular response to epinephrine stimulus
cellular response to lipopolysaccharide
leukocyte migration
negative regulation of relaxation of cardiac muscle
neutrophil chemotaxis
neutrophil homeostasis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
regulation of cardiac muscle cell contraction
regulation of high voltage-gated calcium channel activity
T cell receptor signaling pathway - Gene Ontology Molecular Function:
- 3',5'-cyclic-AMP phosphodiesterase activity
cAMP binding
ion channel binding
metal ion binding - Gene Ontology Cellular Component:
- cell periphery
centrosome
cytosol
dendritic spine
gamma-tubulin complex
membrane
postsynaptic density
synaptic vesicle
Z disc - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Hydrolase
Metal-binding
Phosphoprotein
Polymorphism
Reference proteome
cAMP