Names & Taxonomy
- Uniprot ID:
- Q06520
- Entry Name:
- ST2A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Bile salt sulfotransferase (EC 2.8.2.14) (Dehydroepiandrosterone sulfotransferase) (DHEA-ST) (Hydroxysteroid Sulfotransferase) (HST) (ST2) (ST2A3) (Sulfotransferase 2A1) (ST2A1)
- Gene Names:
- SULT2A1 HST STD
- Gene Names Primary:
- SULT2A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 285
- Sequence:
- MSDDFLWFEGIAFPTMGFRSETLRKVRDEFVIRDEDVIILTYPKSGTNWLAEILCLMHSKGDAKWIQSVPIWERSPWVESEIGYTALSETESPRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVLVSGYFFWKNMKFIKKPKSWEEYFEWFCQGTVLYGSWFDHIHGWMPMREEKNFLLLSYEELKQDTGRTIEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNYSLLSVDYVVDKAQLLRKGVSGDWKNHFTVAQAEDFDKLFQEKMADLPRELFPWE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands.
- Catalytic Activity:
- 3'-phosphoadenylyl sulfate + glycolithocholate = adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate.; 3'-phosphoadenylyl sulfate + taurolithocholate = adenosine 3',5'-bisphosphate + taurolithocholate sulfate.
- Active Site:
- ACT_SITE 99 99 Proton acceptor.
- Cross Reference Drug Bank:
- DB05812 DB00316
- Gene Ontology Go:
- cytoplasm
cytosol
bile-salt sulfotransferase activity
sulfotransferase activity
3'-phosphoadenosine 5'-phosphosulfate metabolic process
bile acid catabolic process
cellular lipid metabolic process
digestion
small molecule metabolic process
steroid metabolic process
sulfation
xenobiotic metabolic process - Gene Ontology Biological Process:
- 3'-phosphoadenosine 5'-phosphosulfate metabolic process
bile acid catabolic process
cellular lipid metabolic process
digestion
small molecule metabolic process
steroid metabolic process
sulfation
xenobiotic metabolic process - Gene Ontology Molecular Function:
- bile-salt sulfotransferase activity
sulfotransferase activity - Gene Ontology Cellular Component:
- cytoplasm
cytosol - Keywords:
- 3D-structure
Bile acid catabolism
Complete proteome
Cytoplasm
Direct protein sequencing
Lipid degradation
Lipid metabolism
Phosphoprotein
Polymorphism
Reference proteome
Steroid metabolism
Transferase - Interacts With:
- P40763; O43704