Names & Taxonomy
- Uniprot ID:
- Q06203
- Entry Name:
- PUR1_HUMAN
- Status:
- reviewed
- Protein Names:
- Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)
- Gene Names:
- PPAT GPAT
- Gene Names Primary:
- PPAT
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 517
- Sequence:
- MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEAPTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFLSIGARYYREVLPGEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIEAPVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGINIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKEKKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW
- Proteomes:
- UP000005640
Function
- Pathway:
- Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.
- Catalytic Activity:
- 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 12 12 Nucleophile.
- Cross Reference Drug Bank:
- DB00544 DB00130 DB01033
- Gene Ontology Go:
- cytosol
4 iron, 4 sulfur cluster binding
amidophosphoribosyltransferase activity
metal ion binding
'de novo' IMP biosynthetic process
cellular response to drug
cellular response to insulin stimulus
G1/S transition of mitotic cell cycle
glutamine catabolic process
kidney development
lactation
maternal process involved in female pregnancy
nucleobase-containing small molecule metabolic process
nucleoside metabolic process
organ regeneration
protein homotetramerization
purine nucleobase biosynthetic process
purine nucleobase metabolic process
purine nucleotide biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
small molecule metabolic process - Gene Ontology Biological Process:
- 'de novo' IMP biosynthetic process
cellular response to drug
cellular response to insulin stimulus
G1/S transition of mitotic cell cycle
glutamine catabolic process
kidney development
lactation
maternal process involved in female pregnancy
nucleobase-containing small molecule metabolic process
nucleoside metabolic process
organ regeneration
protein homotetramerization
purine nucleobase biosynthetic process
purine nucleobase metabolic process
purine nucleotide biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
small molecule metabolic process - Gene Ontology Molecular Function:
- 4 iron, 4 sulfur cluster binding
amidophosphoribosyltransferase activity
metal ion binding - Gene Ontology Cellular Component:
- cytosol
- Keywords:
- 4Fe-4S
Acetylation
Allosteric enzyme
Complete proteome
Glutamine amidotransferase
Glycosyltransferase
Iron
Iron-sulfur
Magnesium
Metal-binding
Purine biosynthesis
Reference proteome
Transferase