Names & Taxonomy

Uniprot ID:
Q06203
Entry Name:
PUR1_HUMAN
Status:
reviewed
Protein Names:
Amidophosphoribosyltransferase (ATase) (EC 2.4.2.14) (Glutamine phosphoribosylpyrophosphate amidotransferase) (GPAT)
Gene Names:
PPAT GPAT
Gene Names Primary:
PPAT
Organism:
Homo sapiens (Human)

Structure

Length:
517
Sequence:
MELEELGIREECGVFGCIASGEWPTQLDVPHVITLGLVGLQHRGQESAGIVTSDGSSVPTFKSHKGMGLVNHVFTEDNLKKLYVSNLGIGHTRYATTGKCELENCQPFVVETLHGKIAVAHNGELVNAARLRKKLLRHGIGLSTSSDSEMITQLLAYTPPQEQDDTPDWVARIKNLMKEAPTAYSLLIMHRDVIYAVRDPYGNRPLCIGRLIPVSDINDKEKKTSETEGWVVSSESCSFLSIGARYYREVLPGEIVEISRHNVQTLDIISRSEGNPVAFCIFEYVYFARPDSMFEDQMVYTVRYRCGQQLAIEAPVDADLVSTVPESATPAALAYAGKCGLPYVEVLCKNRYVGRTFIQPNMRLRQLGVAKKFGVLSDNFKGKRIVLVDDSIVRGNTISPIIKLLKESGAKEVHIRVASPPIKYPCFMGINIPTKEELIANKPEFDHLAEYLGANSVVYLSVEGLVSSVQEGIKFKKQKEKKHDIMIQENGNGLECFEKSGHCTACLTGKYPVELEW
Proteomes:
UP000005640

Function

Pathway:
Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.
Catalytic Activity:
5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H(2)O.
Cofactor:
COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Active Site:
ACT_SITE 12 12 Nucleophile.
Cross Reference Drug Bank:
DB00544 DB00130 DB01033
Gene Ontology Go:
cytosol
4 iron, 4 sulfur cluster binding
amidophosphoribosyltransferase activity
metal ion binding
'de novo' IMP biosynthetic process
cellular response to drug
cellular response to insulin stimulus
G1/S transition of mitotic cell cycle
glutamine catabolic process
kidney development
lactation
maternal process involved in female pregnancy
nucleobase-containing small molecule metabolic process
nucleoside metabolic process
organ regeneration
protein homotetramerization
purine nucleobase biosynthetic process
purine nucleobase metabolic process
purine nucleotide biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
small molecule metabolic process
Gene Ontology Biological Process:
'de novo' IMP biosynthetic process
cellular response to drug
cellular response to insulin stimulus
G1/S transition of mitotic cell cycle
glutamine catabolic process
kidney development
lactation
maternal process involved in female pregnancy
nucleobase-containing small molecule metabolic process
nucleoside metabolic process
organ regeneration
protein homotetramerization
purine nucleobase biosynthetic process
purine nucleobase metabolic process
purine nucleotide biosynthetic process
purine ribonucleoside monophosphate biosynthetic process
small molecule metabolic process
Gene Ontology Molecular Function:
4 iron, 4 sulfur cluster binding
amidophosphoribosyltransferase activity
metal ion binding
Gene Ontology Cellular Component:
cytosol
Keywords:
4Fe-4S
Acetylation
Allosteric enzyme
Complete proteome
Glutamine amidotransferase
Glycosyltransferase
Iron
Iron-sulfur
Magnesium
Metal-binding
Purine biosynthesis
Reference proteome
Transferase

Publication

PubMed ID:
8380692 8106516 15489334 21269460 22814378