Names & Taxonomy
- Uniprot ID:
- Q04671
- Entry Name:
- P_HUMAN
- Status:
- reviewed
- Protein Names:
- P protein (Melanocyte-specific transporter protein) (Pink-eyed dilution protein homolog)
- Gene Names:
- OCA2 D15S12 P
- Gene Names Primary:
- OCA2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 838
- Sequence:
- MHLEGRDGRRYPGAPAVELLQTSVPSGLAELVAGKRRLPRGAGGADPSHSCPRGAAGQSSWAPAGQEFASFLTKGRSHSSLPQMSSSRSKDSCFTENTPLLRNSLQEKGSRCIPVYHPEFITAEESWEDSSADWERRYLLSREVSGLSASASSEKGDLLDSPHIRLRLSKLRRCVQWLKVMGLFAFVVLCSILFSLYPDQGKLWQLLALSPLENYSVNLSSHVDSTLLQVDLAGALVASGPSRPGREEHIVVELTQADALGSRWRRPQQVTHNWTVYLNPRRSEHSVMSRTFEVLTRETVSISIRASLQQTQAVPLLMAHQYLRGSVETQVTIATAILAGVYALIIFEIVHRTLAAMLGSLAALAALAVIGDRPSLTHVVEWIDFETLALLFGMMILVAIFSETGFFDYCAVKAYRLSRGRVWAMIIMLCLIAAVLSAFLDNVTTMLLFTPVTIRLCEVLNLDPRQVLIAEVIFTNIGGAATAIGDPPNVIIVSNQELRKMGLDFAGFTAHMFIGICLVLLVCFPLLRLLYWNRKLYNKEPSEIVELKHEIHVWRLTAQRISPASREETAVRRLLLGKVLALEHLLARRLHTFHRQISQEDKNWETNIQELQKKHRISDGILLAKCLTVLGFVIFMFFLNSFVPGIHLDLGWIAILGAIWLLILADIHDFEIILHRVEWATLLFFAALFVLMEALAHLHLIEYVGEQTALLIKMVPEEQRLIAAIVLVVWVSALASSLIDNIPFTATMIPVLLNLSHDPEVGLPAPPLMYALAFGACLGGNGTLIGASANVVCAGIAEQHGYGFSFMEFFRLGFPMMVVSCTVGMCYLLVAHVVVGWN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Melanosome membrane
Function
- Function:
- Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.
- Gene Ontology Go:
- cytoplasm
endoplasmic reticulum membrane
endosome membrane
integral component of membrane
lysosomal membrane
melanosome membrane
L-tyrosine transmembrane transporter activity
transporter activity
cell proliferation
eye pigment biosynthetic process
melanin biosynthetic process
melanocyte differentiation
spermatid development
tyrosine transport - Gene Ontology Biological Process:
- cell proliferation
eye pigment biosynthetic process
melanin biosynthetic process
melanocyte differentiation
spermatid development
tyrosine transport - Gene Ontology Molecular Function:
- L-tyrosine transmembrane transporter activity
transporter activity - Gene Ontology Cellular Component:
- cytoplasm
endoplasmic reticulum membrane
endosome membrane
integral component of membrane
lysosomal membrane
melanosome membrane - Keywords:
- Albinism
Alternative splicing
Complete proteome
Disease mutation
Glycoprotein
Membrane
Polymorphism
Reference proteome
Transmembrane
Transmembrane helix
Transport