Names & Taxonomy

Uniprot ID:
Q03431
Entry Name:
PTH1R_HUMAN
Status:
reviewed
Protein Names:
Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH/PTHrP type I receptor) (PTH/PTHr receptor) (Parathyroid hormone 1 receptor) (PTH1 receptor)
Gene Names:
PTH1R PTHR PTHR1
Gene Names Primary:
PTH1R
Organism:
Homo sapiens (Human)

Structure

Length:
593
Sequence:
MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPASIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETREREVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVKDAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKKWIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVHYIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKPGTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
This is a receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system.
Cross Reference Drug Bank:
DB05829 DB06285
Gene Ontology Go:
apical plasma membrane
basolateral plasma membrane
brush border membrane
cytoplasm
cytosol
extracellular exosome
integral component of plasma membrane
nucleus
plasma membrane
receptor complex
parathyroid hormone receptor activity
peptide hormone binding
protein self-association
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
aging
bone mineralization
bone resorption
cell maturation
cell surface receptor signaling pathway
chondrocyte differentiation
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cell proliferation
osteoblast development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of inositol phosphate biosynthetic process
skeletal system development
Gene Ontology Biological Process:
adenylate cyclase-activating G-protein coupled receptor signaling pathway
adenylate cyclase-modulating G-protein coupled receptor signaling pathway
aging
bone mineralization
bone resorption
cell maturation
cell surface receptor signaling pathway
chondrocyte differentiation
G-protein coupled receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
negative regulation of cell proliferation
osteoblast development
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
positive regulation of cytosolic calcium ion concentration
positive regulation of inositol phosphate biosynthetic process
skeletal system development
Gene Ontology Molecular Function:
parathyroid hormone receptor activity
peptide hormone binding
protein self-association
Gene Ontology Cellular Component:
apical plasma membrane
basolateral plasma membrane
brush border membrane
cytoplasm
cytosol
extracellular exosome
integral component of plasma membrane
nucleus
plasma membrane
receptor complex
Keywords:
3D-structure
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Dwarfism
G-protein coupled receptor
Glycoprotein
Membrane
Phosphoprotein
Receptor
Reference proteome
Signal
Transducer
Transmembrane
Transmembrane helix
Interacts With:
P35222

Publication

PubMed ID:
8386612 8397094 7745008 15489334 10913300 24275569 9737850 18375760 18611381 19674967 20172855 7701349 8703170 9178745 9745456 10487664 11850620 15523647 15240651 15525660 19061984