Names & Taxonomy

Uniprot ID:
Q03426
Entry Name:
KIME_HUMAN
Status:
reviewed
Protein Names:
Mevalonate kinase (MK) (EC 2.7.1.36)
Gene Names:
MVK
Gene Names Primary:
MVK
Organism:
Homo sapiens (Human)

Structure

Length:
396
Sequence:
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm

Function

Function:
May be a regulatory site in cholesterol biosynthetic pathway.
Pathway:
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
Catalytic Activity:
ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.
Enzyme Regulation:
ENZYME REGULATION: Farnesyl- and geranyl-pyrophosphates are competitive inhibitors.
Active Site:
ACT_SITE 204 204 Proton acceptor.
Gene Ontology Go:
cytosol
extracellular exosome
ATP binding
identical protein binding
mevalonate kinase activity
cholesterol biosynthetic process
isopentenyl diphosphate biosynthetic process, mevalonate pathway
isoprenoid biosynthetic process
negative regulation of inflammatory response
small molecule metabolic process
Gene Ontology Biological Process:
cholesterol biosynthetic process
isopentenyl diphosphate biosynthetic process, mevalonate pathway
isoprenoid biosynthetic process
negative regulation of inflammatory response
small molecule metabolic process
Gene Ontology Molecular Function:
ATP binding
identical protein binding
mevalonate kinase activity
Gene Ontology Cellular Component:
cytosol
extracellular exosome
Keywords:
3D-structure
ATP-binding
Cataract
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Cytoplasm
Disease mutation
Kinase
Lipid biosynthesis
Lipid metabolism
Nucleotide-binding
Polymorphism
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transferase
Interacts With:
Itself; Q9NUX5

Publication

PubMed ID:
1377680 8302606 11313768 15489334 14730012 21269460 22983302 24781643 10417275 10401001 10369261 10369262 11313769 15536479