Names & Taxonomy
- Uniprot ID:
- Q02880
- Entry Name:
- TOP2B_HUMAN
- Status:
- reviewed
- Protein Names:
- DNA topoisomerase 2-beta (EC 5.99.1.3) (DNA topoisomerase II, beta isozyme)
- Gene Names:
- TOP2B
- Gene Names Primary:
- TOP2B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1626
- Sequence:
- MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMFN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus, nucleolus.
Function
- Function:
- Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
- Catalytic Activity:
- ATP-dependent breakage, passage and rejoining of double-stranded DNA.
- Cofactor:
- COFACTOR: Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
- Active Site:
- ACT_SITE 826 826 O-(5'-phospho-DNA)-tyrosine intermediate.
- Cross Reference Drug Bank:
- DB00970 DB00694 DB00380 DB00773
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
nucleus
ATP binding
chromatin binding
DNA binding, bending
DNA topoisomerase type II (ATP-hydrolyzing) activity
enzyme binding
histone deacetylase binding
metal ion binding
protein C-terminus binding
protein heterodimerization activity
protein kinase C binding
axonogenesis
cellular protein metabolic process
DNA topological change
forebrain development
mitotic DNA integrity checkpoint
neuron migration
post-translational protein modification
protein sumoylation
resolution of meiotic recombination intermediates
sister chromatid segregation - Gene Ontology Biological Process:
- axonogenesis
cellular protein metabolic process
DNA topological change
forebrain development
mitotic DNA integrity checkpoint
neuron migration
post-translational protein modification
protein sumoylation
resolution of meiotic recombination intermediates
sister chromatid segregation - Gene Ontology Molecular Function:
- ATP binding
chromatin binding
DNA binding, bending
DNA topoisomerase type II (ATP-hydrolyzing) activity
enzyme binding
histone deacetylase binding
metal ion binding
protein C-terminus binding
protein heterodimerization activity
protein kinase C binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm
nucleus - Keywords:
- 3D-structure
ATP-binding
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
DNA-binding
Isomerase
Isopeptide bond
Magnesium
Metal-binding
Nucleotide-binding
Nucleus
Phosphoprotein
Reference proteome
Topoisomerase
Ubl conjugation