Names & Taxonomy

Uniprot ID:
Q02413
Entry Name:
DSG1_HUMAN
Status:
reviewed
Protein Names:
Desmoglein-1 (Cadherin family member 4) (Desmosomal glycoprotein 1) (DG1) (DGI) (Pemphigus foliaceus antigen)
Gene Names:
DSG1 CDHF4
Gene Names Primary:
DSG1
Organism:
Homo sapiens (Human)

Structure

Length:
1049
Sequence:
MDWSFFRVVAMLFIFLVVVEVNSEFRIQVRDYNTKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQQVTYRISGVGIDQPPYGIFVINQKTGEINITSIVDREVTPFFIIYCRALNSMGQDLERPLELRVRVLDINDNPPVFSMATFAGQIEENSNANTLVMILNATDADEPNNLNSKIAFKIIRQEPSDSPMFIINRNTGEIRTMNNFLDREQYGQYALAVRGSDRDGGADGMSAECECNIKILDVNDNIPYMEQSSYTIEIQENTLNSNLLEIRVIDLDEEFSANWMAVIFFISGNEGNWFEIEMNERTNVGILKVVKPLDYEAMQSLQLSIGVRNKAEFHHSIMSQYKLKASAISVTVLNVIEGPVFRPGSKTYVVTGNMGSNDKVGDFVATDLDTGRPSTTVRYVMGNNPADLLAVDSRTGKLTLKNKVTKEQYNMLGGKYQGTILSIDDNLQRTCTGTININIQSFGNDDRTNTEPNTKITTNTGRQESTSSTNYDTSTTSTDSSQVYSSEPGNGAKDLLSDNVHFGPAGIGLLIMGFLVLGLVPFLMICCDCGGAPRSAAGFEPVPECSDGAIHSWAVEGPQPEPRDITTVIPQIPPDNANIIECIDNSGVYTNEYGGREMQDLGGGERMTGFELTEGVKTSGMPEICQEYSGTLRRNSMRECREGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDDSFLDTLGPKFKKLADISLGKESYPDLDPSWPPQSTEPVCLPQETEPVVSGHPPISPHFGTTTVISESTYPSGPGVLHPKPILDPLGYGNVTVTESYTTSDTLKPSVHVHDNRPASNVVVTERVVGPISGADLHGMLEMPDLRDGSNVIVTERVIAPSSSLPTSLTIHHPRESSNVVVTERVIQPTSGMIGSLSMHPELANAHNVIVTERVVSGAGVTGISGTTGISGGIGSSGLVGTSMGAGSGALSGAGISGGGIGLSSLGGTASIGHMRSSSDHHFNQTIGSASPSTARSRITKYSTVQYSK
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Gene Ontology Go:
apical plasma membrane
cytoplasmic side of plasma membrane
cytosol
desmosome
extracellular exosome
integral component of membrane
lateral plasma membrane
plasma membrane
calcium ion binding
gamma-catenin binding
toxic substance binding
apoptotic process
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell junction assembly
cellular component disassembly involved in execution phase of apoptosis
homophilic cell adhesion via plasma membrane adhesion molecules
maternal process involved in female pregnancy
programmed cell death
protein stabilization
response to progesterone
single organismal cell-cell adhesion
Gene Ontology Biological Process:
apoptotic process
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cell-cell junction assembly
cellular component disassembly involved in execution phase of apoptosis
homophilic cell adhesion via plasma membrane adhesion molecules
maternal process involved in female pregnancy
programmed cell death
protein stabilization
response to progesterone
single organismal cell-cell adhesion
Gene Ontology Molecular Function:
calcium ion binding
gamma-catenin binding
toxic substance binding
Gene Ontology Cellular Component:
apical plasma membrane
cytoplasmic side of plasma membrane
cytosol
desmosome
extracellular exosome
integral component of membrane
lateral plasma membrane
plasma membrane
Keywords:
Alternative splicing
Calcium
Cell adhesion
Cell junction
Cell membrane
Cleavage on pair of basic residues
Complete proteome
Glycoprotein
Hypotrichosis
Membrane
Metal-binding
Palmoplantar keratoderma
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Signal
Transmembrane
Transmembrane helix

Publication

PubMed ID:
1711210 1770008 14702039 16177791 10332028 16740002 19759396 20068231 21269460 23974871