Names & Taxonomy
- Uniprot ID:
- Q02127
- Entry Name:
- PYRD_HUMAN
- Status:
- reviewed
- Protein Names:
- Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase)
- Gene Names:
- DHODH
- Gene Names Primary:
- DHODH
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 395
- Sequence:
- MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion inner membrane
Function
- Function:
- Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
- Pathway:
- Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.
- Catalytic Activity:
- (S)-dihydroorotate + a quinone = orotate + a quinol.
- Cofactor:
- COFACTOR: Name=FMN; Xref=ChEBI:CHEBI:58210;
- Active Site:
- ACT_SITE 214 214 Nucleophile.
- Cross Reference Drug Bank:
- DB01117 DB01097 DB08880
- Gene Ontology Go:
- integral component of membrane
mitochondrial inner membrane
mitochondrion
neuronal cell body
nucleoplasm
dihydroorotate dehydrogenase activity
drug binding
FMN binding
ubiquinone binding
'de novo' pyrimidine nucleobase biosynthetic process
'de novo' UMP biosynthetic process
female pregnancy
lactation
nucleobase-containing small molecule metabolic process
positive regulation of apoptotic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside biosynthetic process
regulation of mitochondrial fission
response to caffeine
response to drug
response to starvation
small molecule metabolic process - Gene Ontology Biological Process:
- 'de novo' pyrimidine nucleobase biosynthetic process
'de novo' UMP biosynthetic process
female pregnancy
lactation
nucleobase-containing small molecule metabolic process
positive regulation of apoptotic process
pyrimidine nucleobase metabolic process
pyrimidine nucleoside biosynthetic process
regulation of mitochondrial fission
response to caffeine
response to drug
response to starvation
small molecule metabolic process - Gene Ontology Molecular Function:
- dihydroorotate dehydrogenase activity
drug binding
FMN binding
ubiquinone binding - Gene Ontology Cellular Component:
- integral component of membrane
mitochondrial inner membrane
mitochondrion
neuronal cell body
nucleoplasm - Keywords:
- 3D-structure
Complete proteome
Disease mutation
FMN
Flavoprotein
Membrane
Mitochondrion
Mitochondrion inner membrane
Oxidoreductase
Polymorphism
Pyrimidine biosynthesis
Reference proteome
Transit peptide
Transmembrane
Transmembrane helix