Names & Taxonomy

Uniprot ID:
Q01959
Entry Name:
SC6A3_HUMAN
Status:
reviewed
Protein Names:
Sodium-dependent dopamine transporter (DA transporter) (DAT) (Solute carrier family 6 member 3)
Gene Names:
SLC6A3 DAT1
Gene Names Primary:
SLC6A3
Organism:
Homo sapiens (Human)

Structure

Length:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cell membrane

Function

Function:
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Cross Reference Drug Bank:
DB00543 DB00182 DB06413 DB00289 DB00245 DB00865 DB01156 DB01161 DB01114 DB00215 DB00907 DB06701 DB01576 DB00937 DB01146 DB00988 DB00476 DB01363 DB01175 DB01463 DB00458 DB08824 DB01255 DB00408 DB00579 DB01577 DB00422 DB06148 DB00370 DB00745 DB01149 DB00454 DB00830 DB00191 DB00721 DB00852 DB01104 DB01105 DB00726 DB00285
Gene Ontology Go:
axon
cell surface
cytoplasm
flotillin complex
integral component of membrane
integral component of plasma membrane
neuronal cell body
plasma membrane
presynapse
dopamine binding
dopamine transmembrane transporter activity
dopamine:sodium symporter activity
drug binding
metal ion binding
monoamine transmembrane transporter activity
adenohypophysis development
aging
dopamine biosynthetic process
dopamine catabolic process
dopamine transport
dopamine uptake involved in synaptic transmission
lactation
locomotory behavior
monoamine transport
neurotransmitter biosynthetic process
positive regulation of multicellular organism growth
prepulse inhibition
regulation of dopamine metabolic process
response to cAMP
response to cocaine
response to drug
response to ethanol
response to iron ion
response to nicotine
sensory perception of smell
synaptic transmission
transmembrane transport
Gene Ontology Biological Process:
adenohypophysis development
aging
dopamine biosynthetic process
dopamine catabolic process
dopamine transport
dopamine uptake involved in synaptic transmission
lactation
locomotory behavior
monoamine transport
neurotransmitter biosynthetic process
positive regulation of multicellular organism growth
prepulse inhibition
regulation of dopamine metabolic process
response to cAMP
response to cocaine
response to drug
response to ethanol
response to iron ion
response to nicotine
sensory perception of smell
synaptic transmission
transmembrane transport
Gene Ontology Molecular Function:
dopamine:sodium symporter activity
dopamine binding
dopamine transmembrane transporter activity
drug binding
metal ion binding
monoamine transmembrane transporter activity
Gene Ontology Cellular Component:
axon
cell surface
cytoplasm
flotillin complex
integral component of membrane
integral component of plasma membrane
neuronal cell body
plasma membrane
presynapse
Keywords:
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
Dystonia
Glycoprotein
Membrane
Metal-binding
Neurodegeneration
Neurotransmitter transport
Parkinsonism
Polymorphism
Reference proteome
Sodium
Symport
Transmembrane
Transmembrane helix
Transport
Interacts With:
P14416; P37840

Publication

PubMed ID:
1359373 1406597 8302271 9300814 10889531 11304827 17934207 15489334 7637582 1353885 11343649 12177201 15505207 10391209 16959974 19478460 21179162