Names & Taxonomy
- Uniprot ID:
- Q01581
- Entry Name:
- HMCS1_HUMAN
- Status:
- reviewed
- Protein Names:
- Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)
- Gene Names:
- HMGCS1 HMGCS
- Gene Names Primary:
- HMGCS1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 520
- Sequence:
- MPGSLPLNAEACWPKDVGIVALEIYFPSQYVDQAELEKYDGVDAGKYTIGLGQAKMGFCTDREDINSLCMTVVQNLMERNNLSYDCIGRLEVGTETIIDKSKSVKTNLMQLFEESGNTDIEGIDTTNACYGGTAAVFNAVNWIESSSWDGRYALVVAGDIAVYATGNARPTGGVGAVALLIGPNAPLIFERGLRGTHMQHAYDFYKPDMLSEYPIVDGKLSIQCYLSALDRCYSVYCKKIHAQWQKEGNDKDFTLNDFGFMIFHSPYCKLVQKSLARMLLNDFLNDQNRDKNSIYSGLEAFGDVKLEDTYFDRDVEKAFMKASSELFSQKTKASLLVSNQNGNMYTSSVYGSLASVLAQYSPQQLAGKRIGVFSYGSGLAATLYSLKVTQDATPGSALDKITASLCDLKSRLDSRTGVAPDVFAENMKLREDTHHLVNYIPQGSIDSLFEGTWYLVRVDEKHRRTYARRPTPNDDTLDEGVGLVHSNIATEHIPSPAKKVPRLPATAAEPEAAVISNGEH
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
- Pathway:
- Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 2/3.
- Catalytic Activity:
- Acetyl-CoA + H(2)O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.
- Active Site:
- ACT_SITE 95 95 Proton donor/acceptor.
- Gene Ontology Go:
- cytoplasm
cytosol
nucleoplasm
nucleus
plasma membrane
drug binding
hydroxymethylglutaryl-CoA synthase activity
isomerase activity
organic acid binding
brain development
cellular lipid metabolic process
cellular response to cholesterol
cellular response to follicle-stimulating hormone stimulus
cholesterol biosynthetic process
isoprenoid biosynthetic process
lipid metabolic process
liver development
male gonad development
response to drug
response to lipoprotein particle
response to low light intensity stimulus
response to purine-containing compound
response to tellurium ion
response to vitamin E
small molecule metabolic process - Gene Ontology Biological Process:
- brain development
cellular lipid metabolic process
cellular response to cholesterol
cellular response to follicle-stimulating hormone stimulus
cholesterol biosynthetic process
isoprenoid biosynthetic process
lipid metabolic process
liver development
male gonad development
response to drug
response to lipoprotein particle
response to low light intensity stimulus
response to purine-containing compound
response to tellurium ion
response to vitamin E
small molecule metabolic process - Gene Ontology Molecular Function:
- drug binding
hydroxymethylglutaryl-CoA synthase activity
isomerase activity
organic acid binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
nucleoplasm
nucleus
plasma membrane - Keywords:
- 3D-structure
Acetylation
Cholesterol biosynthesis
Cholesterol metabolism
Complete proteome
Cytoplasm
Lipid biosynthesis
Lipid metabolism
Phosphoprotein
Reference proteome
Steroid biosynthesis
Steroid metabolism
Sterol biosynthesis
Sterol metabolism
Transferase