Names & Taxonomy
- Uniprot ID:
- Q00796
- Entry Name:
- DHSO_HUMAN
- Status:
- reviewed
- Protein Names:
- Sorbitol dehydrogenase (EC 1.1.1.14) (L-iditol 2-dehydrogenase)
- Gene Names:
- SORD
- Gene Names Primary:
- SORD
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 357
- Sequence:
- MAAAAKPNNLSLVVHGPGDLRLENYPIPEPGPNEVLLRMHSVGICGSDVHYWEYGRIGNFIVKKPMVLGHEASGTVEKVGSSVKHLKPGDRVAIEPGAPRENDEFCKMGRYNLSPSIFFCATPPDDGNLCRFYKHNAAFCYKLPDNVTFEEGALIEPLSVGIHACRRGGVTLGHKVLVCGAGPIGMVTLLVAKAMGAAQVVVTDLSATRLSKAKEIGADLVLQISKESPQEIARKVEGQLGCKPEVTIECTGAEASIQAGIYATRSGGNLVLVGLGSEMTTVPLLHAAIREVDIKGVFRYCNTWPVAISMLASKSVNVKPLVTHRFPLEKALEAFETFKKGLGLKIMLKCDPSDQNP
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion membrane
Function
- Function:
- Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm.
- Catalytic Activity:
- L-iditol + NAD(+) = L-sorbose + NADH.
- Cofactor:
- COFACTOR: Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
- Gene Ontology Go:
- cytosol
extracellular exosome
extracellular space
membrane
mitochondrial membrane
motile cilium
carbohydrate binding
D-xylulose reductase activity
L-iditol 2-dehydrogenase activity
NAD binding
zinc ion binding
carbohydrate metabolic process
fructose biosynthetic process
fructose metabolic process
glucose metabolic process
glucuronate catabolic process to xylulose 5-phosphate
L-xylitol catabolic process
L-xylitol metabolic process
response to cadmium ion
response to copper ion
response to drug
response to hormone
response to nutrient levels
response to osmotic stress
small molecule metabolic process
sorbitol catabolic process
sperm motility - Gene Ontology Biological Process:
- carbohydrate metabolic process
fructose biosynthetic process
fructose metabolic process
glucose metabolic process
glucuronate catabolic process to xylulose 5-phosphate
L-xylitol catabolic process
L-xylitol metabolic process
response to cadmium ion
response to copper ion
response to drug
response to hormone
response to nutrient levels
response to osmotic stress
small molecule metabolic process
sorbitol catabolic process
sperm motility - Gene Ontology Molecular Function:
- carbohydrate binding
D-xylulose reductase activity
L-iditol 2-dehydrogenase activity
NAD binding
zinc ion binding - Gene Ontology Cellular Component:
- cytosol
extracellular exosome
extracellular space
membrane
mitochondrial membrane
motile cilium - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Cell projection
Cilium
Complete proteome
Direct protein sequencing
Flagellum
Membrane
Metal-binding
Mitochondrion
NAD
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Zinc