Names & Taxonomy
- Uniprot ID:
- Q00610
- Entry Name:
- CLH1_HUMAN
- Status:
- reviewed
- Protein Names:
- Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
- Gene Names:
- CLTC CLH17 CLTCL2 KIAA0034
- Gene Names Primary:
- CLTC
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1675
- Sequence:
- MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasmic vesicle membrane
Function
- Function:
- Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
- Gene Ontology Go:
- clathrin coat
clathrin coat of coated pit
clathrin coat of trans-Golgi network vesicle
clathrin complex
clathrin-coated endocytic vesicle membrane
clathrin-coated vesicle
cytosol
endolysosome membrane
extracellular exosome
extracellular vesicle
focal adhesion
intracellular membrane-bounded organelle
melanosome
membrane
plasma membrane
protein complex
spindle
trans-Golgi network membrane
clathrin light chain binding
double-stranded RNA binding
poly(A) RNA binding
protein kinase binding
structural molecule activity
antigen processing and presentation of exogenous peptide antigen via MHC class II
intracellular protein transport
membrane organization
mitotic nuclear division
negative regulation of hyaluronan biosynthetic process
negative regulation of protein localization to plasma membrane
osteoblast differentiation
post-Golgi vesicle-mediated transport
receptor internalization
receptor-mediated endocytosis
retrograde transport, endosome to Golgi
transferrin transport - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class II
intracellular protein transport
membrane organization
mitotic nuclear division
negative regulation of hyaluronan biosynthetic process
negative regulation of protein localization to plasma membrane
osteoblast differentiation
post-Golgi vesicle-mediated transport
receptor internalization
receptor-mediated endocytosis
retrograde transport, endosome to Golgi
transferrin transport - Gene Ontology Molecular Function:
- clathrin light chain binding
double-stranded RNA binding
poly(A) RNA binding
protein kinase binding
structural molecule activity - Gene Ontology Cellular Component:
- clathrin coat
clathrin-coated endocytic vesicle membrane
clathrin-coated vesicle
clathrin coat of coated pit
clathrin coat of trans-Golgi network vesicle
clathrin complex
cytosol
endolysosome membrane
extracellular exosome
extracellular vesicle
focal adhesion
intracellular membrane-bounded organelle
melanosome
membrane
plasma membrane
protein complex
spindle
trans-Golgi network membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Coated pit
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Membrane
Phosphoprotein
Reference proteome
Repeat - Interacts With:
- O00291; P10242; Q01968; Q07912; O75674