Names & Taxonomy

Uniprot ID:
Q00610
Entry Name:
CLH1_HUMAN
Status:
reviewed
Protein Names:
Clathrin heavy chain 1 (Clathrin heavy chain on chromosome 17) (CLH-17)
Gene Names:
CLTC CLH17 CLTCL2 KIAA0034
Gene Names Primary:
CLTC
Organism:
Homo sapiens (Human)

Structure

Length:
1675
Sequence:
MAQILPIRFQEHLQLQNLGINPANIGFSTLTMESDKFICIREKVGEQAQVVIIDMNDPSNPIRRPISADSAIMNPASKVIALKAGKTLQIFNIEMKSKMKAHTMTDDVTFWKWISLNTVALVTDNAVYHWSMEGESQPVKMFDRHSSLAGCQIINYRTDAKQKWLLLTGISAQQNRVVGAMQLYSVDRKVSQPIEGHAASFAQFKMEGNAEESTLFCFAVRGQAGGKLHIIEVGTPPTGNQPFPKKAVDVFFPPEAQNDFPVAMQISEKHDVVFLITKYGYIHLYDLETGTCIYMNRISGETIFVTAPHEATAGIIGVNRKGQVLSVCVEEENIIPYITNVLQNPDLALRMAVRNNLAGAEELFARKFNALFAQGNYSEAAKVAANAPKGILRTPDTIRRFQSVPAQPGQTSPLLQYFGILLDQGQLNKYESLELCRPVLQQGRKQLLEKWLKEDKLECSEELGDLVKSVDPTLALSVYLRANVPNKVIQCFAETGQVQKIVLYAKKVGYTPDWIFLLRNVMRISPDQGQQFAQMLVQDEEPLADITQIVDVFMEYNLIQQCTAFLLDALKNNRPSEGPLQTRLLEMNLMHAPQVADAILGNQMFTHYDRAHIAQLCEKAGLLQRALEHFTDLYDIKRAVVHTHLLNPEWLVNYFGSLSVEDSLECLRAMLSANIRQNLQICVQVASKYHEQLSTQSLIELFESFKSFEGLFYFLGSIVNFSQDPDVHFKYIQAACKTGQIKEVERICRESNCYDPERVKNFLKEAKLTDQLPLIIVCDRFDFVHDLVLYLYRNNLQKYIEIYVQKVNPSRLPVVIGGLLDVDCSEDVIKNLILVVRGQFSTDELVAEVEKRNRLKLLLPWLEARIHEGCEEPATHNALAKIYIDSNNNPERFLRENPYYDSRVVGKYCEKRDPHLACVAYERGQCDLELINVCNENSLFKSLSRYLVRRKDPELWGSVLLESNPYRRPLIDQVVQTALSETQDPEEVSVTVKAFMTADLPNELIELLEKIVLDNSVFSEHRNLQNLLILTAIKADRTRVMEYINRLDNYDAPDIANIAISNELFEEAFAIFRKFDVNTSAVQVLIEHIGNLDRAYEFAERCNEPAVWSQLAKAQLQKGMVKEAIDSYIKADDPSSYMEVVQAANTSGNWEELVKYLQMARKKARESYVETELIFALAKTNRLAELEEFINGPNNAHIQQVGDRCYDEKMYDAAKLLYNNVSNFGRLASTLVHLGEYQAAVDGARKANSTRTWKEVCFACVDGKEFRLAQMCGLHIVVHADELEELINYYQDRGYFEELITMLEAALGLERAHMGMFTELAILYSKFKPQKMREHLELFWSRVNIPKVLRAAEQAHLWAELVFLYDKYEEYDNAIITMMNHPTDAWKEGQFKDIITKVANVELYYRAIQFYLEFKPLLLNDLLMVLSPRLDHTRAVNYFSKVKQLPLVKPYLRSVQNHNNKSVNESLNNLFITEEDYQALRTSIDAYDNFDNISLAQRLEKHELIEFRRIAAYLFKGNNRWKQSVELCKKDSLYKDAMQYASESKDTELAEELLQWFLQEEKRECFGACLFTCYDLLRPDVVLETAWRHNIMDFAMPYFIQVMKEYLTKVDKLDASESLRKEEEQATETQPIVYGQPQLMLTAGPSVAVPPQAPFGYGYTAPPYGQPQPGFGYSM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasmic vesicle membrane

Function

Function:
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network.
Gene Ontology Go:
clathrin coat
clathrin coat of coated pit
clathrin coat of trans-Golgi network vesicle
clathrin complex
clathrin-coated endocytic vesicle membrane
clathrin-coated vesicle
cytosol
endolysosome membrane
extracellular exosome
extracellular vesicle
focal adhesion
intracellular membrane-bounded organelle
melanosome
membrane
plasma membrane
protein complex
spindle
trans-Golgi network membrane
clathrin light chain binding
double-stranded RNA binding
poly(A) RNA binding
protein kinase binding
structural molecule activity
antigen processing and presentation of exogenous peptide antigen via MHC class II
intracellular protein transport
membrane organization
mitotic nuclear division
negative regulation of hyaluronan biosynthetic process
negative regulation of protein localization to plasma membrane
osteoblast differentiation
post-Golgi vesicle-mediated transport
receptor internalization
receptor-mediated endocytosis
retrograde transport, endosome to Golgi
transferrin transport
Gene Ontology Biological Process:
antigen processing and presentation of exogenous peptide antigen via MHC class II
intracellular protein transport
membrane organization
mitotic nuclear division
negative regulation of hyaluronan biosynthetic process
negative regulation of protein localization to plasma membrane
osteoblast differentiation
post-Golgi vesicle-mediated transport
receptor internalization
receptor-mediated endocytosis
retrograde transport, endosome to Golgi
transferrin transport
Gene Ontology Molecular Function:
clathrin light chain binding
double-stranded RNA binding
poly(A) RNA binding
protein kinase binding
structural molecule activity
Gene Ontology Cellular Component:
clathrin coat
clathrin-coated endocytic vesicle membrane
clathrin-coated vesicle
clathrin coat of coated pit
clathrin coat of trans-Golgi network vesicle
clathrin complex
cytosol
endolysosome membrane
extracellular exosome
extracellular vesicle
focal adhesion
intracellular membrane-bounded organelle
melanosome
membrane
plasma membrane
protein complex
spindle
trans-Golgi network membrane
Keywords:
3D-structure
Acetylation
Alternative splicing
Coated pit
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Membrane
Phosphoprotein
Reference proteome
Repeat
Interacts With:
O00291; P10242; Q01968; Q07912; O75674

Publication

PubMed ID:
7584026 17974005 15489334 1765375 12665801 11532990 16314522 17081065 18529014 18691976 18669648 19369195 19690332 19608861 20068231 21269460 22223895 22814378 24275569 25944712 21816279