Names & Taxonomy

Uniprot ID:
P82279
Entry Name:
CRUM1_HUMAN
Status:
reviewed
Protein Names:
Protein crumbs homolog 1
Gene Names:
CRB1
Gene Names Primary:
CRB1
Organism:
Homo sapiens (Human)

Structure

Length:
1406
Sequence:
MALKNINYLLIFYLSFSLLIYIKNSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATTLSFEGDGFLWVKSGSVTTKGSVCNIALRFQTVQPMALLLFRSNRDVFVKLELLSGYIHLSIQVNNQSKVLLFISHNTSDGEWHFVEVIFAEAVTLTLIDDSCKEKCIAKAPTPLESDQSICAFQNSFLGGLPVGMTSNGVALLNFYNMPSTPSFVGCLQDIKIDWNHITLENISSGSSLNVKAGCVRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNCLREYVAGRFGQDDSTGYVIFTLDESYGDTISLSMFVRTLQPSGLLLALENSTYQYIRVWLERGRLAMLTPNSPKLVVKFVLNDGNVHLISLKIKPYKIELYQSSQNLGFISASTWKIEKGDVIYIGGLPDKQETELNGGFFKGCIQDVRLNNQNLEFFPNPTNNASLNPVLVNVTQGCAGDNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFECIANAVFNGQSGQILFRSNGNITRELTNITFGFRTRDANVIILHAEKEPEFLNISIQDSRLFFQLQSGNSFYMLSLTSLQSVNDGTWHEVTLSMTDPLSQTSRWQMEVDNETPFVTSTIATGSLNFLKDNTDIYVGDRAIDNIKGLQGCLSTIEIGGIYLSYFENVHGFINKPQEEQFLKISTNSVVTGCLQLNVCNSNPCLHGGNCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNCSDRVAAYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFAGERCEVDLADDLISDIFTTIGSVTVALLLILLLAIVASVVTSNKRATQGTYSPSRQEKEGSRVEMWNLMPPPAMERLI
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Isoform 1: Apical cell membrane; Single-pass type I membrane protein. Note=Distributed at the apical membrane of all retinal epithelial cells. Located in the apical membrane of the adherens junction in outer limiting membrane (OLM) of the retina.; Isoform 2: Secreted.

Function

Function:
Plays a role in photoreceptor morphogenesis in the retina. May maintain cell polarization and adhesion.
Gene Ontology Go:
apical plasma membrane
extracellular region
integral component of membrane
microvillus
calcium ion binding
cell-cell signaling
establishment or maintenance of cell polarity
eye photoreceptor cell development
plasma membrane organization
Gene Ontology Biological Process:
cell-cell signaling
establishment or maintenance of cell polarity
eye photoreceptor cell development
plasma membrane organization
Gene Ontology Molecular Function:
calcium ion binding
Gene Ontology Cellular Component:
apical plasma membrane
extracellular region
integral component of membrane
microvillus
Keywords:
3D-structure
Alternative splicing
Calcium
Cell membrane
Complete proteome
Disease mutation
Disulfide bond
EGF-like domain
Glycoprotein
Leber congenital amaurosis
Membrane
Polymorphism
Reference proteome
Repeat
Retinitis pigmentosa
Secreted
Signal
Transmembrane
Transmembrane helix
Interacts With:
Q8NI35

Publication

PubMed ID:
10508521 11734541 15914641 17974005 14702039 16710414 15489334 12567265 11389483 11231775 11559858 12573663 12700176 12843338 15024725 15459956 15623792 15691574 16205573 17128490 16936081 16959974 17438615 17724218 18055821 18682808 19140180 19956407 20108431 20683928 20591486 21987686 20956273 22128245 21602930 22065545 22334370