Names & Taxonomy
- Uniprot ID:
- P78540
- Entry Name:
- ARGI2_HUMAN
- Status:
- reviewed
- Protein Names:
- Arginase-2, mitochondrial (EC 3.5.3.1) (Kidney-type arginase) (Non-hepatic arginase) (Type II arginase)
- Gene Names:
- ARG2
- Gene Names Primary:
- ARG2
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 354
- Sequence:
- MSLRGSLSRLLQTRVHSILKKSVHSVAVIGAPFSQGQKRKGVEHGPAAIREAGLMKRLSSLGCHLKDFGDLSFTPVPKDDLYNNLIVNPRSVGLANQELAEVVSRAVSDGYSCVTLGGDHSLAIGTISGHARHCPDLCVVWVDAHADINTPLTTSSGNLHGQPVSFLLRELQDKVPQLPGFSWIKPCISSASIVYIGLRDVDPPEHFILKNYDIQYFSMRDIDRLGIQKVMERTFDLLIGKRQRPIHLSFDIDAFDPTLAPATGTPVVGGLTYREGMYIAEEIHNTGLLSALDLVEVNPQLATSEEEAKTTANLAVDVIASSFGQTREGGHIVYDQLPTPSSPDESENQARVRI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Mitochondrion.
Function
- Function:
- May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
- Pathway:
- Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1.
- Catalytic Activity:
- L-arginine + H(2)O = L-ornithine + urea.
- Cofactor:
- COFACTOR: Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Cross Reference Drug Bank:
- DB00125 DB00129
- Gene Ontology Go:
- mitochondrial matrix
mitochondrion
arginase activity
metal ion binding
arginine metabolic process
cellular nitrogen compound metabolic process
nitric oxide biosynthetic process
polyamine metabolic process
small molecule metabolic process
striated muscle contraction
urea cycle
ureteric bud development - Gene Ontology Biological Process:
- arginine metabolic process
cellular nitrogen compound metabolic process
nitric oxide biosynthetic process
polyamine metabolic process
small molecule metabolic process
striated muscle contraction
urea cycle
ureteric bud development - Gene Ontology Molecular Function:
- arginase activity
metal ion binding - Gene Ontology Cellular Component:
- mitochondrial matrix
mitochondrion - Keywords:
- 3D-structure
Arginine metabolism
Complete proteome
Hydrolase
Manganese
Metal-binding
Mitochondrion
Polymorphism
Reference proteome
Transit peptide
Urea cycle