Names & Taxonomy
- Uniprot ID:
- P78417
- Entry Name:
- GSTO1_HUMAN
- Status:
- reviewed
- Protein Names:
- Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R)
- Gene Names:
- GSTO1 GSTTLP28
- Gene Names Primary:
- GSTO1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 241
- Sequence:
- MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPWFERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYGL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytosol
Function
- Function:
- Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
- Catalytic Activity:
- RX + glutathione = HX + R-S-glutathione.
- Enzyme Regulation:
- ENZYME REGULATION: Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.
- Active Site:
- ACT_SITE 32 32 Nucleophile.
- Cross Reference Drug Bank:
- DB00143 DB00163
- Gene Ontology Go:
- axon
basement membrane
cell body
cytoplasm
cytosol
extracellular exosome
myelin sheath
nuclear membrane
glutathione dehydrogenase (ascorbate) activity
glutathione transferase activity
methylarsonate reductase activity
oxidoreductase activity
cellular oxidant detoxification
cellular response to arsenic-containing substance
glutathione derivative biosynthetic process
glutathione metabolic process
L-ascorbic acid biosynthetic process
L-ascorbic acid metabolic process
methylation
negative regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process - Gene Ontology Biological Process:
- cellular oxidant detoxification
cellular response to arsenic-containing substance
glutathione derivative biosynthetic process
glutathione metabolic process
L-ascorbic acid biosynthetic process
L-ascorbic acid metabolic process
methylation
negative regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process - Gene Ontology Molecular Function:
- glutathione dehydrogenase (ascorbate) activity
glutathione transferase activity
methylarsonate reductase activity
oxidoreductase activity - Gene Ontology Cellular Component:
- axon
basement membrane
cell body
cytoplasm
cytosol
extracellular exosome
myelin sheath
nuclear membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transferase - Interacts With:
- P04792