Names & Taxonomy

Uniprot ID:
P78417
Entry Name:
GSTO1_HUMAN
Status:
reviewed
Protein Names:
Glutathione S-transferase omega-1 (GSTO-1) (EC 2.5.1.18) (Glutathione S-transferase omega 1-1) (GSTO 1-1) (Glutathione-dependent dehydroascorbate reductase) (EC 1.8.5.1) (Monomethylarsonic acid reductase) (MMA(V) reductase) (EC 1.20.4.2) (S-(Phenacyl)glutathione reductase) (SPG-R)
Gene Names:
GSTO1 GSTTLP28
Gene Names Primary:
GSTO1
Organism:
Homo sapiens (Human)

Structure

Length:
241
Sequence:
MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKPEWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELFSKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPWFERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYGL
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Cytoplasm, cytosol

Function

Function:
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Catalytic Activity:
RX + glutathione = HX + R-S-glutathione.
Enzyme Regulation:
ENZYME REGULATION: Monomethylarsonic acid reductase activity is competitively inhibited by 1-chloro 2,4-dinitrobenzene (CDNB) and by deoxycholate.
Active Site:
ACT_SITE 32 32 Nucleophile.
Cross Reference Drug Bank:
DB00143 DB00163
Gene Ontology Go:
axon
basement membrane
cell body
cytoplasm
cytosol
extracellular exosome
myelin sheath
nuclear membrane
glutathione dehydrogenase (ascorbate) activity
glutathione transferase activity
methylarsonate reductase activity
oxidoreductase activity
cellular oxidant detoxification
cellular response to arsenic-containing substance
glutathione derivative biosynthetic process
glutathione metabolic process
L-ascorbic acid biosynthetic process
L-ascorbic acid metabolic process
methylation
negative regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process
Gene Ontology Biological Process:
cellular oxidant detoxification
cellular response to arsenic-containing substance
glutathione derivative biosynthetic process
glutathione metabolic process
L-ascorbic acid biosynthetic process
L-ascorbic acid metabolic process
methylation
negative regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of ryanodine-sensitive calcium-release channel activity
positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
small molecule metabolic process
xenobiotic catabolic process
xenobiotic metabolic process
Gene Ontology Molecular Function:
glutathione dehydrogenase (ascorbate) activity
glutathione transferase activity
methylarsonate reductase activity
oxidoreductase activity
Gene Ontology Cellular Component:
axon
basement membrane
cell body
cytoplasm
cytosol
extracellular exosome
myelin sheath
nuclear membrane
Keywords:
3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Oxidoreductase
Phosphoprotein
Polymorphism
Reference proteome
Transferase
Interacts With:
P04792

Publication

PubMed ID:
10783391 12928150 17974005 15164054 15489334 11271497 11511179 17226937 18028863 19413330 19608861 21269460 24275569 25944712 21106529 12618591