Names & Taxonomy
- Uniprot ID:
- P68371
- Entry Name:
- TBB4B_HUMAN
- Status:
- reviewed
- Protein Names:
- Tubulin beta-4B chain (Tubulin beta-2 chain) (Tubulin beta-2C chain)
- Gene Names:
- TUBB4B TUBB2C
- Gene Names Primary:
- TUBB4B
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 445
- Sequence:
- MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEVA
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, cytoskeleton.
Function
- Function:
- Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
- Cross Reference Drug Bank:
- DB00518 DB00643
- Gene Ontology Go:
- cytoskeleton
cytosol
extracellular exosome
extracellular vesicle
microtubule
myelin sheath
nucleus
double-stranded RNA binding
GTP binding
GTPase activity
MHC class I protein binding
structural constituent of cytoskeleton
unfolded protein binding
'de novo' posttranslational protein folding
cellular protein metabolic process
G2/M transition of mitotic cell cycle
microtubule-based process
mitotic cell cycle
movement of cell or subcellular component
natural killer cell mediated cytotoxicity
organelle organization
protein folding - Gene Ontology Biological Process:
- 'de novo' posttranslational protein folding
cellular protein metabolic process
G2/M transition of mitotic cell cycle
microtubule-based process
mitotic cell cycle
movement of cell or subcellular component
natural killer cell mediated cytotoxicity
organelle organization
protein folding - Gene Ontology Molecular Function:
- double-stranded RNA binding
GTPase activity
GTP binding
MHC class I protein binding
structural constituent of cytoskeleton
unfolded protein binding - Gene Ontology Cellular Component:
- cytoskeleton
cytosol
extracellular exosome
extracellular vesicle
microtubule
myelin sheath
nucleus - Keywords:
- Acetylation
Complete proteome
Cytoplasm
Cytoskeleton
GTP-binding
Isopeptide bond
Microtubule
Nucleotide-binding
Phosphoprotein
Reference proteome