Names & Taxonomy
- Uniprot ID:
- P68104
- Entry Name:
- EF1A1_HUMAN
- Status:
- reviewed
- Protein Names:
- Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor Tu) (EF-Tu) (Eukaryotic elongation factor 1 A-1) (eEF1A-1) (Leukocyte receptor cluster member 7)
- Gene Names:
- EEF1A1 EEF1A EF1A LENG7
- Gene Names Primary:
- EEF1A1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 462
- Sequence:
- MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPPLGRFAVRDMRQTVAVGVIKAVDKKAAGAGKVTKSAQKAQKAK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm. Nucleus. Nucleus, nucleolus. Note=Colocalizes with DLC1 at actin-rich regions in the cell periphery. Translocates together with ZPR1 from the cytoplasm to the nucleus and nucleolus after treatment with mitogens.
Function
- Function:
- This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
- Gene Ontology Go:
- cortical actin cytoskeleton
cytoplasm
cytoplasmic side of lysosomal membrane
cytosol
eukaryotic translation elongation factor 1 complex
extracellular exosome
extracellular space
membrane
nucleolus
nucleus
ruffle membrane
GTP binding
GTPase activity
poly(A) RNA binding
protein kinase binding
translation elongation factor activity
tRNA binding
cellular protein metabolic process
cellular response to epidermal growth factor stimulus
gene expression
regulation of chaperone-mediated autophagy
regulation of transcription, DNA-templated
transcription, DNA-templated
translation
translational elongation - Gene Ontology Biological Process:
- cellular protein metabolic process
cellular response to epidermal growth factor stimulus
gene expression
regulation of chaperone-mediated autophagy
regulation of transcription, DNA-templated
transcription, DNA-templated
translation
translational elongation - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
poly(A) RNA binding
protein kinase binding
translation elongation factor activity
tRNA binding - Gene Ontology Cellular Component:
- cortical actin cytoskeleton
cytoplasm
cytoplasmic side of lysosomal membrane
cytosol
eukaryotic translation elongation factor 1 complex
extracellular exosome
extracellular space
membrane
nucleolus
nucleus
ruffle membrane - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Elongation factor
GTP-binding
Methylation
Nucleotide-binding
Nucleus
Phosphoprotein
Protein biosynthesis
Reference proteome
Transcription
Transcription regulation
Ubl conjugation - Interacts With:
- Q8NFJ9; Q00987; P54725; Q9NYA1; P63104; Q05516; Q8IUH5