Names & Taxonomy
- Uniprot ID:
- P63010
- Entry Name:
- AP2B1_HUMAN
- Status:
- reviewed
- Protein Names:
- AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)
- Gene Names:
- AP2B1 ADTB2 CLAPB1
- Gene Names Primary:
- AP2B1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 937
- Sequence:
- MTDSKYFTTNKKGEIFELKAELNNEKKEKRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHPNSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQKRPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATLCENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLTLLTAIVKLFLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEKPLISEETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGTTTATNLEQPQVIPSQGDLLGDLLNLDLGPPVNVPQVSSMQMGAVDLLGGGLDSLVGQSFIPSSVPATFAPSPTPAVVSSGLNDLFELSTGIGMAPGGYVAPKAVWLPAVKAKGLEISGTFTHRQGHIYMEMNFTNKALQHMTDFAIQFNKNSFGVIPSTPLAIHTPLMPNQSIDVSLPLNTLGPVMKMEPLNNLQVAVKNNIDVFYFSCLIPLNVLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEGQDMLYQSLKLTNGIWILAELRIQPGNPNYTLSLKCRAPEVSQYIYQVYDSILKN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X- (Y-X-X-Phi) and -X-X-X-L- endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 beta subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins; at least some clathrin-associated sorting proteins (CLASPs) are recognized by their -X(1,2)-F-X-X--X-X-X-R motif. The AP-2 beta subunit binds to clathrin heavy chain, promoting clathrin lattice assembly; clathrin displaces at least some CLASPs from AP2B1 which probably then can be positioned for further coat assembly.
- Gene Ontology Go:
- AP-2 adaptor complex
clathrin-coated endocytic vesicle membrane
cytosol
endocytic vesicle membrane
endolysosome membrane
intracellular membrane-bounded organelle
membrane
plasma membrane
trans-Golgi network
clathrin binding
protein transporter activity
signal sequence binding
antigen processing and presentation of exogenous peptide antigen via MHC class II
aorta development
axon guidance
clathrin coat assembly
clathrin-mediated endocytosis
coronary vasculature development
ephrin receptor signaling pathway
epidermal growth factor receptor signaling pathway
intracellular protein transport
negative regulation of epidermal growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
regulation of defense response to virus by virus
synaptic transmission
ventricular septum development
viral process - Gene Ontology Biological Process:
- antigen processing and presentation of exogenous peptide antigen via MHC class II
aorta development
axon guidance
clathrin coat assembly
clathrin-mediated endocytosis
coronary vasculature development
ephrin receptor signaling pathway
epidermal growth factor receptor signaling pathway
intracellular protein transport
negative regulation of epidermal growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
regulation of defense response to virus by virus
synaptic transmission
ventricular septum development
viral process - Gene Ontology Molecular Function:
- clathrin binding
protein transporter activity
signal sequence binding - Gene Ontology Cellular Component:
- AP-2 adaptor complex
clathrin-coated endocytic vesicle membrane
cytosol
endocytic vesicle membrane
endolysosome membrane
intracellular membrane-bounded organelle
membrane
plasma membrane
trans-Golgi network - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Cell membrane
Coated pit
Complete proteome
Endocytosis
Membrane
Phosphoprotein
Protein transport
Reference proteome
Transport - Interacts With:
- Q9UHB7; Q9UHB7-2; Q9Y6Q5; P84092; Q6NVW7; Q5SW96; Q16626; Q8WWR8-2; P12236; Q9NVV9; Q99757; Q01081; Q8N4L5