Names & Taxonomy
- Uniprot ID:
- P62942
- Entry Name:
- FKB1A_HUMAN
- Status:
- reviewed
- Protein Names:
- Peptidyl-prolyl cis-trans isomerase FKBP1A (PPIase FKBP1A) (EC 5.2.1.8) (12 kDa FK506-binding protein) (12 kDa FKBP) (FKBP-12) (Calstabin-1) (FK506-binding protein 1A) (FKBP-1A) (Immunophilin FKBP12) (Rotamase)
- Gene Names:
- FKBP1A FKBP1 FKBP12
- Gene Names Primary:
- FKBP1A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 108
- Sequence:
- MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm.
Function
- Function:
- Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
- Catalytic Activity:
- Peptidylproline (omega=180) = peptidylproline (omega=0).
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by both FK506 and rapamycin.
- Cross Reference Drug Bank:
- DB00337 DB00877 DB00864
- Gene Ontology Go:
- cytoplasm
cytosol
endoplasmic reticulum membrane
extracellular exosome
extracellular matrix
membrane
terminal cisterna
Z disc
activin binding
FK506 binding
ion channel binding
macrolide binding
peptidyl-prolyl cis-trans isomerase activity
signal transducer activity
SMAD binding
transforming growth factor beta receptor binding
type I transforming growth factor beta receptor binding
'de novo' protein folding
amyloid fibril formation
calcium ion transmembrane transport
chaperone-mediated protein folding
extracellular fibril organization
heart morphogenesis
heart trabecula formation
negative regulation of protein phosphatase type 2B activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of protein binding
positive regulation of protein ubiquitination
protein folding
protein maturation by protein folding
protein peptidyl-prolyl isomerization
protein refolding
regulation of activin receptor signaling pathway
regulation of amyloid precursor protein catabolic process
regulation of immune response
regulation of protein localization
regulation of ryanodine-sensitive calcium-release channel activity
SMAD protein complex assembly
T cell activation
transforming growth factor beta receptor signaling pathway
ventricular cardiac muscle tissue morphogenesis - Gene Ontology Biological Process:
- 'de novo' protein folding
amyloid fibril formation
calcium ion transmembrane transport
chaperone-mediated protein folding
extracellular fibril organization
heart morphogenesis
heart trabecula formation
negative regulation of protein phosphatase type 2B activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of protein binding
positive regulation of protein ubiquitination
protein folding
protein maturation by protein folding
protein peptidyl-prolyl isomerization
protein refolding
regulation of activin receptor signaling pathway
regulation of amyloid precursor protein catabolic process
regulation of immune response
regulation of protein localization
regulation of ryanodine-sensitive calcium-release channel activity
SMAD protein complex assembly
T cell activation
transforming growth factor beta receptor signaling pathway
ventricular cardiac muscle tissue morphogenesis - Gene Ontology Molecular Function:
- activin binding
FK506 binding
ion channel binding
macrolide binding
peptidyl-prolyl cis-trans isomerase activity
signal transducer activity
SMAD binding
transforming growth factor beta receptor binding
type I transforming growth factor beta receptor binding - Gene Ontology Cellular Component:
- cytoplasm
cytosol
endoplasmic reticulum membrane
extracellular exosome
extracellular matrix
membrane
terminal cisterna
Z disc - Keywords:
- 3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Isomerase
Reference proteome
Rotamase - Interacts With:
- P36896; Q9NZD4; P42345; Q92736; O15105; P36897