Names & Taxonomy
- Uniprot ID:
- P62826
- Entry Name:
- RAN_HUMAN
- Status:
- reviewed
- Protein Names:
- GTP-binding nuclear protein Ran (Androgen receptor-associated protein 24) (GTPase Ran) (Ras-like protein TC4) (Ras-related nuclear protein)
- Gene Names:
- RAN ARA24 OK/SW-cl.81
- Gene Names Orf:
- OK/SW-cl.81
- Gene Names Primary:
- RAN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 216
- Sequence:
- MAAQGEPQVQFKLVLVGDGGTGKTTFVKRHLTGEFEKKYVATLGVEVHPLVFHTNRGPIKFNVWDTAGQEKFGGLRDGYYIQAQCAIIMFDVTSRVTYKNVPNWHRDLVRVCENIPIVLCGNKVDIKDRKVKAKSIVFHRKKNLQYYDISAKSNYNFEKPFLWLARKLIGDPNLEFVAMPALAPPEVVMDPALAAQYEHDLEVAQTTALPDEDDDL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm. Melanosome. Nucleus envelope
Function
- Function:
- GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity). The complex with BIRC5/ survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2.
- Gene Ontology Go:
- centriole
cytoplasm
cytosol
extracellular exosome
male germ cell nucleus
manchette
melanosome
membrane
midbody
nuclear pore
nucleolus
nucleoplasm
nucleus
recycling endosome
RNA nuclear export complex
sperm flagellum
androgen receptor binding
chromatin binding
GDP binding
GTP binding
GTPase activity
poly(A) RNA binding
transcription coactivator activity
actin cytoskeleton organization
androgen receptor signaling pathway
cell division
cellular protein complex localization
cellular response to mineralocorticoid stimulus
DNA metabolic process
gene expression
gene silencing by RNA
hippocampus development
intracellular transport of virus
mitotic nuclear division
mitotic spindle organization
positive regulation of protein binding
positive regulation of transcription, DNA-templated
pre-miRNA export from nucleus
protein export from nucleus
protein import into nucleus, translocation
protein localization to nucleolus
ribosomal large subunit export from nucleus
ribosomal small subunit export from nucleus
signal transduction
small GTPase mediated signal transduction
small molecule metabolic process
spermatid development
tRNA processing
viral life cycle
viral process - Gene Ontology Biological Process:
- actin cytoskeleton organization
androgen receptor signaling pathway
cell division
cellular protein complex localization
cellular response to mineralocorticoid stimulus
DNA metabolic process
gene expression
gene silencing by RNA
hippocampus development
intracellular transport of virus
mitotic nuclear division
mitotic spindle organization
positive regulation of protein binding
positive regulation of transcription, DNA-templated
pre-miRNA export from nucleus
protein export from nucleus
protein import into nucleus, translocation
protein localization to nucleolus
ribosomal large subunit export from nucleus
ribosomal small subunit export from nucleus
signal transduction
small GTPase mediated signal transduction
small molecule metabolic process
spermatid development
tRNA processing
viral life cycle
viral process - Gene Ontology Molecular Function:
- androgen receptor binding
chromatin binding
GDP binding
GTPase activity
GTP binding
poly(A) RNA binding
transcription coactivator activity - Gene Ontology Cellular Component:
- centriole
cytoplasm
cytosol
extracellular exosome
male germ cell nucleus
manchette
melanosome
membrane
midbody
nuclear pore
nucleolus
nucleoplasm
nucleus
recycling endosome
RNA nuclear export complex
sperm flagellum - Keywords:
- 3D-structure
Acetylation
Cell cycle
Cell division
Complete proteome
Cytoplasm
Direct protein sequencing
GTP-binding
Host-virus interaction
Isopeptide bond
Mitosis
Nucleotide-binding
Nucleus
Polymorphism
Protein transport
Reference proteome
Transport
Ubl conjugation - Interacts With:
- Q8WVL7; O15392; O94829; P61970; Q8WUF5; P18754; Q92973; Q13625; Q99986; Q86Y07-1; Q86Y07-5