Names & Taxonomy
- Uniprot ID:
- P62491
- Entry Name:
- RB11A_HUMAN
- Status:
- reviewed
- Protein Names:
- Ras-related protein Rab-11A (Rab-11) (YL8)
- Gene Names:
- RAB11A RAB11
- Gene Names Primary:
- RAB11A
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 216
- Sequence:
- MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane
Function
- Function:
- The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes.
- Gene Ontology Go:
- axon
cleavage furrow
cytoplasmic vesicle
cytoplasmic vesicle membrane
cytosol
extracellular exosome
Golgi apparatus
mitochondrion
multivesicular body
perinuclear region of cytoplasm
phagocytic vesicle
plasma membrane
protein complex
recycling endosome
recycling endosome membrane
spindle pole
trans-Golgi network
transport vesicle
vesicle
GTP binding
GTPase activity
microtubule binding
myosin V binding
syntaxin binding
astral microtubule organization
cytokinesis
establishment of protein localization to membrane
establishment of protein localization to organelle
establishment of vesicle localization
exosomal secretion
melanosome transport
mitotic metaphase plate congression
mitotic spindle assembly
multivesicular body assembly
neuron projection development
organelle organization
plasma membrane to endosome transport
positive regulation of axon extension
positive regulation of epithelial cell migration
positive regulation of G2/M transition of mitotic cell cycle
protein localization to plasma membrane
protein transport
regulation of long-term neuronal synaptic plasticity
regulation of multivesicular body size
regulation of protein transport
regulation of vesicle-mediated transport
renal water homeostasis
small GTPase mediated signal transduction
transmembrane transport
vesicle-mediated transport
water transport - Gene Ontology Biological Process:
- astral microtubule organization
cytokinesis
establishment of protein localization to membrane
establishment of protein localization to organelle
establishment of vesicle localization
exosomal secretion
melanosome transport
mitotic metaphase plate congression
mitotic spindle assembly
multivesicular body assembly
neuron projection development
organelle organization
plasma membrane to endosome transport
positive regulation of axon extension
positive regulation of epithelial cell migration
positive regulation of G2/M transition of mitotic cell cycle
protein localization to plasma membrane
protein transport
regulation of long-term neuronal synaptic plasticity
regulation of multivesicular body size
regulation of protein transport
regulation of vesicle-mediated transport
renal water homeostasis
small GTPase mediated signal transduction
transmembrane transport
vesicle-mediated transport
water transport - Gene Ontology Molecular Function:
- GTPase activity
GTP binding
microtubule binding
myosin V binding
syntaxin binding - Gene Ontology Cellular Component:
- axon
cleavage furrow
cytoplasmic vesicle
cytoplasmic vesicle membrane
cytosol
extracellular exosome
Golgi apparatus
mitochondrion
multivesicular body
perinuclear region of cytoplasm
phagocytic vesicle
plasma membrane
protein complex
recycling endosome
recycling endosome membrane
spindle pole
trans-Golgi network
transport vesicle
vesicle - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Cell cycle
Cell membrane
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Endosome
GTP-binding
Lipoprotein
Membrane
Methylation
Nucleotide-binding
Prenylation
Protein transport
Reference proteome
Transport - Interacts With:
- Q7LBR1; Q7L804; Q9BXF6; Q5T4F4
Publication
- PubMed ID:
- 1704119 9662449 14702039 16572171 15489334 11495908 12470645 11786538 11994279 15280022 15173169 15304524 15181150 16148947 15601896 15689490 17082457 17462998 17229837 18329369 19542231 20890297 20190753 21269460 21282656 21255211 22613832 23535298 24023390 26506309 25944712 16034420 15837192 17007872 17030804 16905101