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Names & Taxonomy

Uniprot ID:: P62158
Entry Name:: CALM_HUMAN
Status:: reviewed
Protein Names:: Calmodulin (CaM)
Gene Names:: CALM1 CALM CAM CAM1; CALM2 CAM2 CAMB; CALM3 CALML2 CAM3 CAMC CAMIII
Gene Names Orf:: ; ;
Gene Names Primary:: CALM1; CALM2; CALM3
Organism:: Homo sapiens (Human)

Structure

Length:: 149
Sequence:: MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
Proteomes:: UP000005640

Subcellular location

Subcellular Location:: Cytoplasm, cytoskeleton, spindle

Function

Function:: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis.
Cross Reference Drug Bank:: DB01429 DB01244 DB00477 DB00527 DB01023 DB04841 DB00623 DB00753 DB00836 DB01065 DB00622 DB01115 DB00850 DB00925 DB01100 DB01069 DB00831
Gene Ontology Go:: centrosome
cytoplasm
cytosol
extracellular exosome
extracellular region
growth cone
nucleoplasm
nucleus
plasma membrane
sarcomere
spindle microtubule
spindle pole
vesicle
voltage-gated potassium channel complex
calcium ion binding
ion channel binding
N-terminal myristoylation domain binding
nitric-oxide synthase regulator activity
phospholipase binding
protein domain specific binding
protein kinase binding
protein phosphatase activator activity
protein serine/threonine kinase activator activity
thioesterase binding
titin binding
activation of adenylate cyclase activity
activation of MAPKK activity
activation of phospholipase C activity
axon guidance
blood coagulation
carbohydrate metabolic process
detection of calcium ion
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G-protein coupled receptor signaling pathway
G2/M transition of mitotic cell cycle
glucose metabolic process
glycogen catabolic process
innate immune response
inositol phosphate metabolic process
insulin receptor signaling pathway
MAPK cascade
membrane organization
muscle contraction
negative regulation of peptidyl-threonine phosphorylation
negative regulation of ryanodine-sensitive calcium-release channel activity
neurotrophin TRK receptor signaling pathway
nitric oxide metabolic process
phototransduction, visible light
platelet activation
platelet degranulation
positive regulation of cyclic nucleotide metabolic process
positive regulation of cyclic-nucleotide phosphodiesterase activity
positive regulation of DNA binding
positive regulation of nitric-oxide synthase activity
positive regulation of peptidyl-threonine phosphorylation
positive regulation of phosphoprotein phosphatase activity
positive regulation of protein autophosphorylation
positive regulation of protein dephosphorylation
positive regulation of protein serine/threonine kinase activity
positive regulation of ryanodine-sensitive calcium-release channel activity
Ras protein signal transduction
regulation of cardiac muscle contraction
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of cytokinesis
regulation of heart rate
regulation of high voltage-gated calcium channel activity
regulation of nitric-oxide synthase activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of rhodopsin mediated signaling pathway
response to amphetamine
response to calcium ion
response to corticosterone
rhodopsin mediated signaling pathway
signal transduction
small GTPase mediated signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
substantia nigra development
synaptic transmission
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Biological Process:: activation of adenylate cyclase activity
activation of MAPKK activity
activation of phospholipase C activity
axon guidance
blood coagulation
carbohydrate metabolic process
detection of calcium ion
epidermal growth factor receptor signaling pathway
Fc-epsilon receptor signaling pathway
fibroblast growth factor receptor signaling pathway
G2/M transition of mitotic cell cycle
glucose metabolic process
glycogen catabolic process
G-protein coupled receptor signaling pathway
innate immune response
inositol phosphate metabolic process
insulin receptor signaling pathway
MAPK cascade
membrane organization
muscle contraction
negative regulation of peptidyl-threonine phosphorylation
negative regulation of ryanodine-sensitive calcium-release channel activity
neurotrophin TRK receptor signaling pathway
nitric oxide metabolic process
phototransduction, visible light
platelet activation
platelet degranulation
positive regulation of cyclic nucleotide metabolic process
positive regulation of cyclic-nucleotide phosphodiesterase activity
positive regulation of DNA binding
positive regulation of nitric-oxide synthase activity
positive regulation of peptidyl-threonine phosphorylation
positive regulation of phosphoprotein phosphatase activity
positive regulation of protein autophosphorylation
positive regulation of protein dephosphorylation
positive regulation of protein serine/threonine kinase activity
positive regulation of ryanodine-sensitive calcium-release channel activity
Ras protein signal transduction
regulation of cardiac muscle contraction
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
regulation of cell communication by electrical coupling involved in cardiac conduction
regulation of cytokinesis
regulation of heart rate
regulation of high voltage-gated calcium channel activity
regulation of nitric-oxide synthase activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of rhodopsin mediated signaling pathway
response to amphetamine
response to calcium ion
response to corticosterone
rhodopsin mediated signaling pathway
signal transduction
small GTPase mediated signal transduction
small molecule metabolic process
stimulatory C-type lectin receptor signaling pathway
substantia nigra development
synaptic transmission
vascular endothelial growth factor receptor signaling pathway
Gene Ontology Molecular Function:: calcium ion binding
ion channel binding
nitric-oxide synthase regulator activity
N-terminal myristoylation domain binding
phospholipase binding
protein domain specific binding
protein kinase binding
protein phosphatase activator activity
protein serine/threonine kinase activator activity
thioesterase binding
titin binding
Gene Ontology Cellular Component:: centrosome
cytoplasm
cytosol
extracellular exosome
extracellular region
growth cone
nucleoplasm
nucleus
plasma membrane
sarcomere
spindle microtubule
spindle pole
vesicle
voltage-gated potassium channel complex
Keywords:: 3D-structure
Acetylation
Calcium
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Disease mutation
Isopeptide bond
Long QT syndrome
Metal-binding
Methylation
Phosphoprotein
Polymorphism
Reference proteome
Repeat
Ubl conjugation
Interacts With:: Q9Z305; P29274; P49407; P32121; Q8NCR3; Q13936; O43303; P40136; P53355; P00533; P25445; O95259; O95259-2; A0JP07; Q9H0B3; P26645; Q9HD67; Q96PM5; Q14524; Q8WZ42; P63104

Names & Taxonomy

Structure

Subcellular location

Function

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