Names & Taxonomy

Uniprot ID:
P61769
Entry Name:
B2MG_HUMAN
Status:
reviewed
Protein Names:
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]
Gene Names:
B2M CDABP0092 HDCMA22P
Gene Names Orf:
CDABP0092 HDCMA22P
Gene Names Primary:
B2M
Organism:
Homo sapiens (Human)

Structure

Length:
119
Sequence:
MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Secreted

Function

Function:
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
Cross Reference Drug Bank:
DB00254
Gene Ontology Go:
cytoplasm
early endosome lumen
early endosome membrane
endoplasmic reticulum lumen
ER to Golgi transport vesicle membrane
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
focal adhesion
Golgi apparatus
Golgi membrane
HFE-transferrin receptor complex
membrane
MHC class I protein complex
phagocytic vesicle membrane
plasma membrane
glycoprotein binding
identical protein binding
antibacterial humoral response
antigen processing and presentation of endogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cellular protein metabolic process
cellular response to iron ion
cellular response to lipopolysaccharide
cytokine-mediated signaling pathway
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
innate immune response
interferon-gamma-mediated signaling pathway
iron ion homeostasis
negative regulation of neuron projection development
negative regulation of receptor binding
positive regulation of ferrous iron binding
positive regulation of ferrous iron import into cell
positive regulation of protein binding
positive regulation of receptor binding
positive regulation of receptor-mediated endocytosis
positive regulation of T cell cytokine production
positive regulation of T cell mediated cytotoxicity
positive regulation of transferrin receptor binding
protein refolding
regulation of defense response to virus by virus
regulation of immune response
regulation of membrane depolarization
response to cadmium ion
response to drug
retina homeostasis
T cell differentiation in thymus
viral process
Gene Ontology Biological Process:
antibacterial humoral response
antigen processing and presentation of endogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
antigen processing and presentation of peptide antigen via MHC class I
cellular protein metabolic process
cellular response to iron ion
cellular response to lipopolysaccharide
cytokine-mediated signaling pathway
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
innate immune response
interferon-gamma-mediated signaling pathway
iron ion homeostasis
negative regulation of neuron projection development
negative regulation of receptor binding
positive regulation of ferrous iron binding
positive regulation of ferrous iron import into cell
positive regulation of protein binding
positive regulation of receptor binding
positive regulation of receptor-mediated endocytosis
positive regulation of T cell cytokine production
positive regulation of T cell mediated cytotoxicity
positive regulation of transferrin receptor binding
protein refolding
regulation of defense response to virus by virus
regulation of immune response
regulation of membrane depolarization
response to cadmium ion
response to drug
retina homeostasis
T cell differentiation in thymus
viral process
Gene Ontology Molecular Function:
glycoprotein binding
identical protein binding
Gene Ontology Cellular Component:
cytoplasm
early endosome lumen
early endosome membrane
endoplasmic reticulum lumen
ER to Golgi transport vesicle membrane
external side of plasma membrane
extracellular exosome
extracellular region
extracellular space
focal adhesion
Golgi apparatus
Golgi membrane
HFE-transferrin receptor complex
membrane
MHC class I protein complex
phagocytic vesicle membrane
plasma membrane
Keywords:
3D-structure
Amyloid
Amyloidosis
Complete proteome
Direct protein sequencing
Disease mutation
Disulfide bond
Glycation
Glycoprotein
Immunity
Immunoglobulin domain
MHC I
Pyrrolidone carboxylic acid
Reference proteome
Secreted
Signal
Interacts With:
Itself; P06126; P29016; Q30201

Publication

PubMed ID:
3312414 16108498 14702039 15489334 11894933 6171820 4586824 3532124 8084451 1336137 25946035 7554280 7918443 21269460 24275569 25944712 3309677 2038058 1390678 7862664 8624812 12119416 12796775 16901902 16491088 17646174 18835253 18395224 19284997 16549777