Names & Taxonomy
- Uniprot ID:
- P61221
- Entry Name:
- ABCE1_HUMAN
- Status:
- reviewed
- Protein Names:
- ATP-binding cassette sub-family E member 1 (2'-5'-oligoadenylate-binding protein) (HuHP68) (RNase L inhibitor) (Ribonuclease 4 inhibitor) (RNS4I)
- Gene Names:
- ABCE1 RLI RNASEL1 RNASELI RNS4I OK/SW-cl.40
- Gene Names Orf:
- OK/SW-cl.40
- Gene Names Primary:
- ABCE1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 599
- Sequence:
- MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISETLCIGCGICIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPGEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPFSVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGEVPVLNVSYKPQKISPKSTGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIENIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm
Function
- Function:
- Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
- Gene Ontology Go:
- cytoplasm
membrane
mitochondrial matrix
mitochondrion
ATP binding
ATPase activity
ribonuclease inhibitor activity
negative regulation of catalytic activity
response to virus
RNA catabolic process
transmembrane transport
viral process - Gene Ontology Biological Process:
- negative regulation of catalytic activity
response to virus
RNA catabolic process
transmembrane transport
viral process - Gene Ontology Molecular Function:
- ATPase activity
ATP binding
ribonuclease inhibitor activity - Gene Ontology Cellular Component:
- cytoplasm
membrane
mitochondrial matrix
mitochondrion - Keywords:
- ATP-binding
Chaperone
Complete proteome
Cytoplasm
Host-virus interaction
Mitochondrion
Nucleotide-binding
Polymorphism
Reference proteome
Repeat - Interacts With:
- P03347-1; Q9WH76