Names & Taxonomy
- Uniprot ID:
- P61073
- Entry Name:
- CXCR4_HUMAN
- Status:
- reviewed
- Protein Names:
- C-X-C chemokine receptor type 4 (CXC-R4) (CXCR-4) (FB22) (Fusin) (HM89) (LCR1) (Leukocyte-derived seven transmembrane domain receptor) (LESTR) (Lipopolysaccharide-associated protein 3) (LAP-3) (LPS-associated protein 3) (NPYRL) (Stromal cell-derived factor 1 receptor) (SDF-1 receptor) (CD antigen CD184)
- Gene Names:
- CXCR4
- Gene Names Primary:
- CXCR4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 352
- Sequence:
- MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cell membrane; Multi-pass membrane protein. Cell junction. Early endosome. Late endosome. Lysosome. Note=In unstimulated cells, diffuse pattern on plasma membrane. On agonist stimulation, colocalizes with ITCH at the plasma membrane where it becomes ubiquitinated. In the presence of antigen, distributes to the immunological synapse forming at the T-cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation cluster (SMAC).
Function
- Function:
- Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development. In the CNS, could mediate hippocampal-neuron survival.
- Cross Reference Drug Bank:
- DB00452 DB06809
- Gene Ontology Go:
- cell junction
cell leading edge
cell surface
cytoplasm
cytoplasmic vesicle
cytoplasmic, membrane-bounded vesicle
early endosome
extracellular exosome
integral component of membrane
late endosome
lysosome
plasma membrane
actin binding
C-X-C chemokine receptor activity
coreceptor activity
drug binding
G-protein coupled receptor activity
myosin light chain binding
ubiquitin binding
ubiquitin protein ligase binding
virus receptor activity
activation of MAPK activity
apoptotic process
calcium-mediated signaling
cardiac muscle contraction
cellular response to cytokine stimulus
dendritic cell chemotaxis
entry into host cell
epithelial cell development
G-protein coupled receptor signaling pathway
inflammatory response
myelin maintenance
neuron migration
neuron recognition
positive regulation of cytosolic calcium ion concentration
positive regulation of oligodendrocyte differentiation
regulation of calcium ion transport
regulation of cell migration
regulation of chemotaxis
regulation of programmed cell death
response to hypoxia
response to virus
telencephalon cell migration
viral process - Gene Ontology Biological Process:
- activation of MAPK activity
apoptotic process
calcium-mediated signaling
cardiac muscle contraction
cellular response to cytokine stimulus
dendritic cell chemotaxis
entry into host cell
epithelial cell development
G-protein coupled receptor signaling pathway
inflammatory response
myelin maintenance
neuron migration
neuron recognition
positive regulation of cytosolic calcium ion concentration
positive regulation of oligodendrocyte differentiation
regulation of calcium ion transport
regulation of cell migration
regulation of chemotaxis
regulation of programmed cell death
response to hypoxia
response to virus
telencephalon cell migration
viral process - Gene Ontology Molecular Function:
- actin binding
coreceptor activity
C-X-C chemokine receptor activity
drug binding
G-protein coupled receptor activity
myosin light chain binding
ubiquitin binding
ubiquitin protein ligase binding
virus receptor activity - Gene Ontology Cellular Component:
- cell junction
cell leading edge
cell surface
cytoplasm
cytoplasmic, membrane-bounded vesicle
cytoplasmic vesicle
early endosome
extracellular exosome
integral component of membrane
late endosome
lysosome
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Endosome
G-protein coupled receptor
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Lysosome
Membrane
Phosphoprotein
Proteoglycan
Receptor
Reference proteome
Sulfation
Transducer
Transmembrane
Transmembrane helix
Ubl conjugation - Interacts With:
- Q04900; P04233; P32302; Q16643; Q07266-1; P35579
Publication
- PubMed ID:
- 8329116 8234909 8325644 8276799 7505609 8629022 9468539 9599023 10480633 9879064 10452968 14702039 15815621 15489334 8752280 8752281 8849450 8929542 9427609 10089882 10074102 10074122 10644702 10825158 10756055 11027346 11276205 12034737 14602072 12692554 17081983 17077324 17197449 18834145 18220336 18669648 19116316 20048153 20228059 20215400 20505072 20068231 21540189 22496149 16725153 18799424 20929726