Names & Taxonomy
- Uniprot ID:
- P60981
- Entry Name:
- DEST_HUMAN
- Status:
- reviewed
- Protein Names:
- Destrin (Actin-depolymerizing factor) (ADF)
- Gene Names:
- DSTN ACTDP DSN
- Gene Names Primary:
- DSTN
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 165
- Sequence:
- MASGVQVADEVCRIFYDMKVRKCSTPEEIKKRKKAVIFCLSADKKCIIVEEGKEILVGDVGVTITDPFKHFVGMLPEKDCRYALYDASFETKESRKEELMFFLWAPELAPLKSKMIYASSKDAIKKKFQGIKHECQANGPEDLNRACIAEKLGGSLIVAFEGCPV
- Proteomes:
- UP000005640
Function
- Function:
- Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
- Gene Ontology Go:
- actin cytoskeleton
cortical actin cytoskeleton
extracellular exosome
actin filament depolymerization
actin filament severing
actin polymerization or depolymerization
positive regulation of actin filament depolymerization - Gene Ontology Biological Process:
- actin filament depolymerization
actin filament severing
actin polymerization or depolymerization
positive regulation of actin filament depolymerization - Gene Ontology Cellular Component:
- actin cytoskeleton
cortical actin cytoskeleton
extracellular exosome - Keywords:
- Acetylation
Actin-binding
Alternative splicing
Complete proteome
Direct protein sequencing
Phosphoprotein
Polymorphism
Reference proteome
Ubl conjugation - Interacts With:
- P60709; P63261; Q549N0; Q1KLZ0; Q86VP1