Names & Taxonomy
- Uniprot ID:
- P60880
- Entry Name:
- SNP25_HUMAN
- Status:
- reviewed
- Protein Names:
- Synaptosomal-associated protein 25 (SNAP-25) (Super protein) (SUP) (Synaptosomal-associated 25 kDa protein)
- Gene Names:
- SNAP25 SNAP
- Gene Names Primary:
- SNAP25
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 206
- Sequence:
- MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Cytoplasm, perinuclear region
Function
- Function:
- t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells.
- Cross Reference Drug Bank:
- DB00083
- Gene Ontology Go:
- cell junction
cytoplasm
cytosol
growth cone
membrane
myelin sheath
neuron projection
perinuclear region of cytoplasm
plasma membrane
presynaptic membrane
SNARE complex
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
trans-Golgi network
calcium-dependent protein binding
SNAP receptor activity
syntaxin-1 binding
associative learning
energy reserve metabolic process
glutamate secretion
locomotory behavior
long-term synaptic potentiation
neurotransmitter secretion
neurotransmitter uptake
regulation of insulin secretion
regulation of neuron projection development
small molecule metabolic process
synaptic transmission
synaptic vesicle docking
synaptic vesicle exocytosis
synaptic vesicle fusion to presynaptic active zone membrane
synaptic vesicle priming - Gene Ontology Biological Process:
- associative learning
energy reserve metabolic process
glutamate secretion
locomotory behavior
long-term synaptic potentiation
neurotransmitter secretion
neurotransmitter uptake
regulation of insulin secretion
regulation of neuron projection development
small molecule metabolic process
synaptic transmission
synaptic vesicle docking
synaptic vesicle exocytosis
synaptic vesicle fusion to presynaptic active zone membrane
synaptic vesicle priming - Gene Ontology Molecular Function:
- calcium-dependent protein binding
SNAP receptor activity
syntaxin-1 binding - Gene Ontology Cellular Component:
- cell junction
cytoplasm
cytosol
growth cone
membrane
myelin sheath
neuron projection
perinuclear region of cytoplasm
plasma membrane
presynaptic membrane
SNARE complex
synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
trans-Golgi network - Keywords:
- 3D-structure
Alternative splicing
Cell junction
Cell membrane
Coiled coil
Complete proteome
Congenital myasthenic syndrome
Cytoplasm
Disease mutation
Lipoprotein
Membrane
Mental retardation
Palmitate
Phosphoprotein
Reference proteome
Repeat
Synapse
Synaptosome - Interacts With:
- Q8IUH5