Names & Taxonomy

Uniprot ID:
P58872
Entry Name:
RHBL3_HUMAN
Status:
reviewed
Protein Names:
Rhomboid-related protein 3 (EC 3.4.21.105) (Ventrhoid transmembrane protein)
Gene Names:
RHBDL3 RHBDL4 VRHO
Gene Names Primary:
RHBDL3
Organism:
Homo sapiens (Human)

Structure

Length:
404
Sequence:
MGEHPSPGPAVAACAEAERIEELEPEAEERLPAAPEDHWKVLFDQFDPGNTGYISTGKFRSLLESHSSKLDPHKREVLLALADSHADGQIGYQDFVSLMSNKRSNSFRQAILQGNRRLSSKALLEEKGLSLSQRLIRHVAYETLPREIDRKWYYDSYTCCPPPWFMITVTLLEVAFFLYNGVSLGQFVLQVTHPRYLKNSLVYHPQLRAQVWRYLTYIFMHAGIEHLGLNVVLQLLVGVPLEMVHGATRIGLVYVAGVVAGSLAVSVADMTAPVVGSSGGVYALVSAHLANIVMNWSGMKCQFKLLRMAVALICMSMEFGRAVWLRFHPSAYPPCPHPSFVAHLGGVAVGITLGVVVLRNYEQRLQDQSLWWIFVAMYTVFVLFAVFWNIFAYTLLDLKLPPPP
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Membrane

Function

Function:
May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.
Catalytic Activity:
Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.
Active Site:
ACT_SITE 278 278 Nucleophile.
Gene Ontology Go:
integral component of membrane
mitochondrial inner membrane
calcium ion binding
serine-type endopeptidase activity
protein processing
Gene Ontology Biological Process:
protein processing
Gene Ontology Molecular Function:
calcium ion binding
serine-type endopeptidase activity
Gene Ontology Cellular Component:
integral component of membrane
mitochondrial inner membrane
Keywords:
Alternative splicing
Complete proteome
Hydrolase
Membrane
Polymorphism
Protease
Reference proteome
Repeat
Serine protease
Transmembrane
Transmembrane helix

Publication

PubMed ID:
11900977 14702039 16625196 15489334