Names & Taxonomy
- Uniprot ID:
- P57789
- Entry Name:
- KCNKA_HUMAN
- Status:
- reviewed
- Protein Names:
- Potassium channel subfamily K member 10 (Outward rectifying potassium channel protein TREK-2) (TREK-2 K(+) channel subunit)
- Gene Names:
- KCNK10 TREK2
- Gene Names Primary:
- KCNK10
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 538
- Sequence:
- MFFLYTDFFLSLVAVPAAAPVCQPKSATNGQPPAPAPTPTPRLSISSRATVVARMEGTSQGGLQTVMKWKTVVAIFVVVVVYLVTGGLVFRALEQPFESSQKNTIALEKAEFLRDHVCVSPQELETLIQHALDADNAGVSPIGNSSNNSSHWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIARVEKVFRKKQVSQTKIRVISTILFILAGCIVFVTIPAVIFKYIEGWTALESIYFVVVTLTTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAHAAEWKANVTAEFRETRRRLSVEIHDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKRSVFAALDTGRFKASSQESINNRPNNLRLKGPEQLNKHGQGASEDNIINKFGSTSRLTKRKNKDLKKTLPEDVQKIYKTFRNYSLDEEKKEEETEKMCNSDNSSTAMLTDCIQQHAELENGMIPTDTKDREPENNSLLEDRN
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane
- Intramembrane:
- INTRAMEM 154 180 Pore-forming; Name=Pore-forming 1.
Function
- Function:
- Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. Activated by arachidonic acid and other naturally occurring unsaturated free fatty acids.
- Gene Ontology Go:
- integral component of plasma membrane
plasma membrane
potassium channel activity
potassium ion leak channel activity
voltage-gated ion channel activity
memory
signal transduction
stabilization of membrane potential
synaptic transmission
transport - Gene Ontology Biological Process:
- memory
signal transduction
stabilization of membrane potential
synaptic transmission
transport - Gene Ontology Molecular Function:
- potassium channel activity
potassium ion leak channel activity
voltage-gated ion channel activity - Gene Ontology Cellular Component:
- integral component of plasma membrane
plasma membrane - Keywords:
- 3D-structure
Alternative splicing
Complete proteome
Glycoprotein
Ion channel
Ion transport
Membrane
Polymorphism
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel