Names & Taxonomy
- Uniprot ID:
- P56817
- Entry Name:
- BACE1_HUMAN
- Status:
- reviewed
- Protein Names:
- Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2)
- Gene Names:
- BACE1 BACE KIAA1149
- Gene Names Primary:
- BACE1
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 501
- Sequence:
- MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWCCLRCLRQQHDDFADDISLLK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane. Note=Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
Function
- Function:
- Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
- Catalytic Activity:
- Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.
- Enzyme Regulation:
- ENZYME REGULATION: Inhibited by RTN3 and RTN4.
- Active Site:
- ACT_SITE 93 93
- Gene Ontology Go:
- axon
cell surface
cytoplasmic vesicle membrane
endoplasmic reticulum lumen
endosome
endosome membrane
Golgi apparatus
Golgi-associated vesicle lumen
integral component of membrane
integral component of plasma membrane
late endosome
multivesicular body
plasma membrane
trans-Golgi network
aspartic-type endopeptidase activity
beta-amyloid binding
beta-aspartyl-peptidase activity
enzyme binding
peptidase activity
beta-amyloid metabolic process
cellular protein metabolic process
membrane protein ectodomain proteolysis
protein catabolic process
proteolysis - Gene Ontology Biological Process:
- beta-amyloid metabolic process
cellular protein metabolic process
membrane protein ectodomain proteolysis
protein catabolic process
proteolysis - Gene Ontology Molecular Function:
- aspartic-type endopeptidase activity
beta-amyloid binding
beta-aspartyl-peptidase activity
enzyme binding
peptidase activity - Gene Ontology Cellular Component:
- axon
cell surface
cytoplasmic vesicle membrane
endoplasmic reticulum lumen
endosome
endosome membrane
Golgi apparatus
Golgi-associated vesicle lumen
integral component of membrane
integral component of plasma membrane
late endosome
multivesicular body
plasma membrane
trans-Golgi network - Keywords:
- 3D-structure
Acetylation
Alternative splicing
Aspartyl protease
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Golgi apparatus
Hydrolase
Membrane
Phosphoprotein
Polymorphism
Protease
Reference proteome
Signal
Transmembrane
Transmembrane helix
Zymogen - Interacts With:
- Q8BNX1; Q14254