Names & Taxonomy
- Uniprot ID:
- P56703
- Entry Name:
- WNT3_HUMAN
- Status:
- reviewed
- Protein Names:
- Proto-oncogene Wnt-3 (Proto-oncogene Int-4 homolog)
- Gene Names:
- WNT3 INT4
- Gene Names Primary:
- WNT3
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 355
- Sequence:
- MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCRNYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIASAGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRPDARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDSASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTCNVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Secreted, extracellular space, extracellular matrix.
Function
- Function:
- Ligand for members of the frizzled family of seven transmembrane receptors. Wnt-3 and Wnt-3a play distinct roles in cell-cell signaling during morphogenesis of the developing neural tube (By similarity).
- Gene Ontology Go:
- endocytic vesicle membrane
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Golgi lumen
plasma membrane
proteinaceous extracellular matrix
Wnt signalosome
frizzled binding
receptor agonist activity
anterior/posterior axis specification
axon guidance
canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
canonical Wnt signaling pathway involved in osteoblast differentiation
cell fate commitment
cell morphogenesis
cellular response to retinoic acid
dorsal/ventral axis specification
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
gamete generation
head morphogenesis
limb bud formation
mammary gland epithelium development
mesoderm formation
negative regulation of axon extension involved in axon guidance
neuron differentiation
positive regulation of collateral sprouting in absence of injury
positive regulation of gene expression
positive regulation of Wnt signaling pathway
Spemann organizer formation at the anterior end of the primitive streak - Gene Ontology Biological Process:
- anterior/posterior axis specification
axon guidance
canonical Wnt signaling pathway
canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
canonical Wnt signaling pathway involved in osteoblast differentiation
cell fate commitment
cell morphogenesis
cellular response to retinoic acid
dorsal/ventral axis specification
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
gamete generation
head morphogenesis
limb bud formation
mammary gland epithelium development
mesoderm formation
negative regulation of axon extension involved in axon guidance
neuron differentiation
positive regulation of collateral sprouting in absence of injury
positive regulation of gene expression
positive regulation of Wnt signaling pathway
Spemann organizer formation at the anterior end of the primitive streak - Gene Ontology Molecular Function:
- frizzled binding
receptor agonist activity - Gene Ontology Cellular Component:
- endocytic vesicle membrane
endoplasmic reticulum lumen
extracellular exosome
extracellular region
extracellular space
Golgi lumen
plasma membrane
proteinaceous extracellular matrix
Wnt signalosome - Keywords:
- Complete proteome
Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Proto-oncogene
Reference proteome
Secreted
Signal
Wnt signaling pathway - Interacts With:
- O75084