Names & Taxonomy

Uniprot ID:
P56696
Entry Name:
KCNQ4_HUMAN
Status:
reviewed
Protein Names:
Potassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4)
Gene Names:
KCNQ4
Gene Names Primary:
KCNQ4
Organism:
Homo sapiens (Human)

Structure

Length:
695
Sequence:
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRAYLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQKSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKGDKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
Proteomes:
UP000005640

Subcellular location

Subcellular Location:
Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells.
Intramembrane:
INTRAMEM 271 292 Pore-forming; Name=Segment H5.

Function

Function:
Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
Cross Reference Drug Bank:
DB04953
Gene Ontology Go:
basal plasma membrane
cytoplasm
integral component of membrane
neuron projection
plasma membrane
voltage-gated potassium channel complex
delayed rectifier potassium channel activity
potassium channel activity
inner ear morphogenesis
negative regulation of synaptic transmission, dopaminergic
potassium ion transport
sensory perception of sound
synaptic transmission
Gene Ontology Biological Process:
inner ear morphogenesis
negative regulation of synaptic transmission, dopaminergic
potassium ion transport
sensory perception of sound
synaptic transmission
Gene Ontology Molecular Function:
delayed rectifier potassium channel activity
potassium channel activity
Gene Ontology Cellular Component:
basal plasma membrane
cytoplasm
integral component of membrane
neuron projection
plasma membrane
voltage-gated potassium channel complex
Keywords:
3D-structure
Alternative splicing
Cell membrane
Coiled coil
Complete proteome
Deafness
Disease mutation
Hearing
Ion channel
Ion transport
Membrane
Non-syndromic deafness
Potassium
Potassium channel
Potassium transport
Reference proteome
Transmembrane
Transmembrane helix
Transport
Voltage-gated channel

Publication

PubMed ID:
10025409 16710414 10713961 11245603 17329207 10369879 10571947 10925378 21242547