Names & Taxonomy
- Uniprot ID:
- P56524
- Entry Name:
- HDAC4_HUMAN
- Status:
- reviewed
- Protein Names:
- Histone deacetylase 4 (HD4) (EC 3.5.1.98)
- Gene Names:
- HDAC4 KIAA0288
- Gene Names Primary:
- HDAC4
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 1084
- Sequence:
- MSSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAVPMDLRLDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHIKQQQEMLAMKHQQELLEHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKESAVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSGVSTSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALKKRPLDVTDSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVAREGSAAPLPLYTSPSLPNITLGLPATGPSAGTAGQQDAERLTLPALQQRLSLFPGTHLTPYLSTSPLERDGGAAHSPLLQHMVLLEQPPAQAPLVTGLGALPLHAQSLVGADRVSPSIHKLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLEKHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAHAQAGVQVKQEPIESDEEEAEPPREVEPGQRQPSEQELLFRQQALLLEQQRIHQLRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLNRQKLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAEKRPDEEPMEEEPPL
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.
Function
- Function:
- Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
- Catalytic Activity:
- Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
- Active Site:
- ACT_SITE 803 803
- Cross Reference Drug Bank:
- DB06603
- Gene Ontology Go:
- A band
actomyosin
cytoplasm
cytosol
histone deacetylase complex
neuromuscular junction
nucleoplasm
nucleus
transcriptional repressor complex
Z disc
activating transcription factor binding
chromatin binding
core promoter binding
histone deacetylase activity
histone deacetylase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
potassium ion binding
protein deacetylase activity
repressing transcription factor binding
RNA polymerase III transcription factor binding
transcription corepressor activity
transcription factor binding
zinc ion binding
B cell activation
B cell differentiation
cardiac muscle hypertrophy in response to stress
cellular response to mechanical stimulus
cellular response to parathyroid hormone stimulus
cellular response to tumor necrosis factor
chromatin remodeling
histone deacetylation
histone H3 deacetylation
histone H4 deacetylation
inflammatory response
negative regulation of cell proliferation
negative regulation of glycolytic process
negative regulation of myotube differentiation
negative regulation of osteoblast differentiation
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription from RNA polymerase II promoter
negative regulation of transcription, DNA-templated
nervous system development
osteoblast development
peptidyl-lysine deacetylation
positive regulation of cell proliferation
positive regulation of lamellipodium assembly
positive regulation of neuron apoptotic process
positive regulation of protein sumoylation
positive regulation of reactive oxygen species biosynthetic process
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of smooth muscle cell migration
positive regulation of smooth muscle cell proliferation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of transcription, DNA-templated
regulation of cardiac muscle contraction by calcium ion signaling
regulation of gene expression, epigenetic
regulation of protein binding
regulation of skeletal muscle fiber development
response to denervation involved in regulation of muscle adaptation
response to drug
response to interleukin-1
skeletal system development
transcription, DNA-templated - Gene Ontology Biological Process:
- B cell activation
B cell differentiation
cardiac muscle hypertrophy in response to stress
cellular response to mechanical stimulus
cellular response to parathyroid hormone stimulus
cellular response to tumor necrosis factor
chromatin remodeling
histone deacetylation
histone H3 deacetylation
histone H4 deacetylation
inflammatory response
negative regulation of cell proliferation
negative regulation of glycolytic process
negative regulation of myotube differentiation
negative regulation of osteoblast differentiation
negative regulation of sequence-specific DNA binding transcription factor activity
negative regulation of transcription, DNA-templated
negative regulation of transcription from RNA polymerase II promoter
nervous system development
osteoblast development
peptidyl-lysine deacetylation
positive regulation of cell proliferation
positive regulation of lamellipodium assembly
positive regulation of neuron apoptotic process
positive regulation of protein sumoylation
positive regulation of reactive oxygen species biosynthetic process
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of smooth muscle cell migration
positive regulation of smooth muscle cell proliferation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of cardiac muscle contraction by calcium ion signaling
regulation of gene expression, epigenetic
regulation of protein binding
regulation of skeletal muscle fiber development
response to denervation involved in regulation of muscle adaptation
response to drug
response to interleukin-1
skeletal system development
transcription, DNA-templated - Gene Ontology Molecular Function:
- activating transcription factor binding
chromatin binding
core promoter binding
histone deacetylase activity
histone deacetylase binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
potassium ion binding
protein deacetylase activity
repressing transcription factor binding
RNA polymerase III transcription factor binding
transcription corepressor activity
transcription factor binding
zinc ion binding - Gene Ontology Cellular Component:
- A band
actomyosin
cytoplasm
cytosol
histone deacetylase complex
neuromuscular junction
nucleoplasm
nucleus
transcriptional repressor complex
Z disc - Keywords:
- 3D-structure
Alternative splicing
Autism spectrum disorder
Chromatin regulator
Coiled coil
Complete proteome
Cytoplasm
Hydrolase
Isopeptide bond
Mental retardation
Metal-binding
Nucleus
Phosphoprotein
Polymorphism
Reference proteome
Repressor
Transcription
Transcription regulation
Ubl conjugation
Zinc - Interacts With:
- Q9H9E1; P10275; P15336; P41182; Q9HCU9; Q96JN2-2; Q01850; O95967; Q08379; P08393; Q15323; O76015; Q6A162; O95751; A9UHW6; Q5JR59; Q8ND90; Q6NUQ1; Q13761; P31947; P63279; P31946; P62258; P61981; Q04917; P63104