Names & Taxonomy
- Uniprot ID:
- P55769
- Entry Name:
- NH2L1_HUMAN
- Status:
- reviewed
- Protein Names:
- NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed]
- Gene Names:
- SNU13 NHP2L1
- Gene Names Primary:
- SNU13
- Organism:
- Homo sapiens (Human)
Structure
- Length:
- 128
- Sequence:
- MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQQSIERLLV
- Proteomes:
- UP000005640
Subcellular location
- Subcellular Location:
- Nucleus, nucleolus
Function
- Function:
- Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.
- Gene Ontology Go:
- box C/D snoRNP complex
nucleolus
nucleoplasm
nucleus
protein complex
spliceosomal complex
ATPase binding
box C/D snoRNA binding
poly(A) RNA binding
RNA binding
U3 snoRNA binding
U4 snRNA binding
U4atac snRNA binding
gene expression
mRNA splicing, via spliceosome
ribosome biogenesis
RNA splicing - Gene Ontology Biological Process:
- gene expression
mRNA splicing, via spliceosome
ribosome biogenesis
RNA splicing - Gene Ontology Molecular Function:
- ATPase binding
box C/D snoRNA binding
poly(A) RNA binding
RNA binding
U3 snoRNA binding
U4atac snRNA binding
U4 snRNA binding - Gene Ontology Cellular Component:
- box C/D snoRNP complex
nucleolus
nucleoplasm
nucleus
protein complex
spliceosomal complex - Keywords:
- 3D-structure
Acetylation
Complete proteome
Direct protein sequencing
Nucleus
Polymorphism
RNA-binding
Reference proteome
Ribonucleoprotein
Spliceosome
mRNA processing
mRNA splicing - Interacts With:
- P04591; Q9UHK0